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GT Biopharma Presents Preclinical Data Demonstrating Second-Generation CD19 Targeting Tri-Specific Killer Engager (TriKE®) Driving Robust NK Cell Function Against B Cell Malignancies at EHA 2022 Congress
Ongoing experiments will evaluate the functionality and efficacy of GTB-7550 in vivoFuture studies will also involve assessments of GTB-7550 TriKE efficacy in
About this update from Gt Biopharma, Inc.
[{"type":"text","content":"Ongoing experiments will evaluate the functionality and efficacy of GTB-7550 in vivoFuture studies will also involve assessments of GTB-7550 TriKE efficacy in other hematologic cancers BRISBANE, Calif., June 10, 2022 (GLOBE NEWSWIRE) -- GT Biopharma, Inc. (“the Company”) (NASDAQ: GTBP), a clinical stage immuno-oncology company focused on developing innovative therapeutics based on the Company’s proprietary tri-specific natural killer (NK) cell engager, TriKE® protein biologic technology platform, announced today, preclinical data in chronic lymphocytic leukemia (“CLL”) to be presented at the European Hematology Association (EHA) 2022 Congress. The poster presentation titled, “Second-Generation CD19 Targeting Tri-Specific Killer Engager Drives Robust NK Cell Function Against B Cell Malignancies,” presented by Dr. Jeff Miller’s laboratory, University of Minnesota. GTB-7550 (“CAM-161519”) is the Company’s CD19-targeted tri-specific killer engager (TriKE) targeted against B-cell lymphomas and is part of GT Biopharma’s portfolio of TriKE product candidates being investigated in several preclinical models against a broad class of solid tumors and hematological cancers. Dr. Gregory Berk, President of R&D and Chief Medical Officer noted, “We are excited to broaden preclinical development of GT Biopharma’s proprietary platform of NK cell immunotherapies to include B cell malignancies. These exciting new data suggests GTB-7550 can be a viable potential CLL treatment option in light of current challenges and shortfalls of current standard of care. We look forward to investigating GTB-7750 as a novel approach with other hematological cancers as well.” Poster Title – “Second-Generation CD19 Targeting Tri-Specific Killer Engager Drives Robust NK Cell Function Against B Cell Malignancies” Background – According to the American Cancer Society, CLL accounts for about one-quarter of the new cases of leukemia. In 2022, an estimated 20,160 people will develop CLL, and about 4,410 will die from CLL. Existing targeted therapies for B cell malignancies work well in a subsegment of the (CLL) patient population, but face limitations such as development of drug resistance and lower treatment efficacy ratio in high-risk patients. Other therapeutic options such as CAR-T cell immunotherapy have failed to produce effective treatment outcomes against CLL, mos...