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GT Biopharma Presents Preclinical Data Demonstrating Novel B7H3+ Tumor Targeting GTB-5550 TriKE® Driving NK Cell Activation and ADCC Against Head and Neck Squamous Cell Carcinomas at AACR Annual Meeting 2022
- Ongoing experiments will evaluate the functionality and efficacy of the B7H3 TriKE in vivo- Future studies will also involve assessments of the B7H3 TriKE
About this update from Gt Biopharma, Inc.
[{"type":"text","content":"- Ongoing experiments will evaluate the functionality and efficacy of the B7H3 TriKE in vivo- Future studies will also involve assessments of the B7H3 TriKE efficacy in the HNSCC tumor microenvironment BRISBANE, Calif., April 11, 2022 (GLOBE NEWSWIRE) -- GT Biopharma, Inc. (“the Company”) (NASDAQ: GTBP), a clinical stage immuno-oncology company focused on developing innovative therapeutics based on the Company's proprietary tri-specific natural killer (NK) cell engager, TriKE® protein biologic technology platform, announced today that it is presenting pre-clinical data at the American Association For Cancer Research Annual Meeting 2022. The poster presentation titled, “#3435: GTB-5550 (cam16-IL15-camB7H3) Tri-specific Killer Engager (TriKE®) Drives NK Cell Activation and ADCC against Head and Neck Squamous Cell Carcinomas,” presented by Dr. Jeff Miller's laboratory, University of Minnesota. GTB-5550 is the Company’s B7H3-targeted tri-specific killer engager (TriKE) and is part of GT Biopharma’s portfolio of TriKE product candidates being investigated in several preclinical models against a broad class of solid tumor cancers. Structurally, GTB-5550 TriKE consists of a humanized camelid nanobody against CD16, a camelid nanobody against B7H3 and a wild type IL-15 sequence between the two engagers, and it functions by bridging the NK and tumor cells. Dr. Gregory Berk, President of R&D and Chief Medical Officer noted, “B7H3 is a novel immune checkpoint of the B7 family and is highly expressed on a variety of human cancers including but not limited to head and neck cancers, melanoma, ovarian cancer, prostate cancer, and brain cancer. Our work with GTB-5550 along with our other lead pipeline asset (GTB-3650) demonstrate remarkable promise in preclinical studies as potential new immunotherapies with high specificity towards targeted cancer cells but not healthy tissue where these immune checkpoint inhibitors are not highly expressed or absent.” Poster Title - “#3435: GTB-5550 (cam16-IL15-camB7H3) Tri-specific Killer Engager (TriKE®) Drives NK Cell Activation and ADCC against Head and Neck Squamous Cell Carcinomas” Background - According to the American Society of Clinical Oncology’s information hub, head and neck cancers account for about 4% of all cancers in the United States. In 2021, an estimated 66,630 people (48,740 men and 17,890 ...