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GT Biopharma Announces GTB-3550 TriKE™ Monotherapy Rescues and Restores NK Cell Immune Surveillance in Relapsed/Refractory AML and MDS Cancer Patients
BEVERLY HILLS, Calif., April 12, 2021 /PRNewswire/ -- GT Biopharma, Inc. (NASDAQ: GTBP), a clinical stage immuno-oncology company focused on developing
About this update from Gt Biopharma, Inc.
[{"type":"text","content":"BEVERLY HILLS, Calif., April 12, 2021 /PRNewswire/ -- GT Biopharma, Inc. (NASDAQ: GTBP), a clinical stage immuno-oncology company focused on developing innovative therapeutics based on the Company's proprietary NK cell engager (TriKE™) protein biologic technology platform, announced today additional interim results from its GTB-3550 TriKE™ first-in-human Phase I/II clinical trial for the treatment of high-risk myelodysplastic syndromes (MDS) and refractory/relapsed acute myeloid leukemia (AML).\n\n \n \n \n \n \n \n\n \nAdditional results show GTB-3550 TriKE™ monotherapy is able to rescue the patient's otherwise exhausted/inhibited/non-functional endogenous NK cell population and target direct killing of the patient's AML and MDS cancer cells without the need for the co-administration addition of supplemental progenitor-derived or autologous/allogenic engineered NK cells. \nGTB-3550 TriKE™ monotherapy has demonstrated clinical benefit in very hard to treat relapsed/refractory AML and high-risk MDS cancer patients by significantly reducing cancer cell (blast) levels and, in some cases, ending transfusion dependency with patients becoming eligible for bone marrow transplant.\nThe ability to use GTB-3550 in a monotherapy setting is a significant competitive and therapeutic advantage, and a major cost savings compared to the co-administration of drug/cell therapy combination regimens. GTB-3550 TriKE™ therapy requires no patient pre-treatment regimens such as myeloablative chemotherapy, and is well tolerated with no signs of cytokine release syndrome (CRS) or other toxicities suggesting GTB-3550 could be used to treat patients earlier in the disease process, whereas complicated and expensive combination drug/cell therapy regimens are expected to be used as late-stage or salvage therapies after all other therapeutic options have been exhausted.\nHighlights from the first nine patients treated with GTB-3550 TriKE™ include:\nUp to 63.7% Reduction in Bone Marrow Blast Levels Resulting in Clinical Benefit Restores Patient's Endogenous NK Cell Function, Proliferation and Immune Surveillance No Progenitor-derived or Autologous/Allogenic Cell Therapy Required No Cytokine Release Syndrome Observed 3 out of the last 5 Patients Treated Respond (25mcg/kg/day to 100mcg/kg/day therapeutic dose range)\"We believe GTB-3550 TriKE™ sets a new standard...