GT BIOPHARMA ANNOUNCES FDA DATA - GTB-3550 TriKE™ REDUCES CANCER CELLS BY 61.7% FOR A HIGH-RISK MYELODYSPLASTIC SYNDROMES (HR-MDS) PATIENT

About this update from Gt Biopharma, Inc.

[{"type":"text","content":"BEVERLY HILLS, Calif, Dec. 21, 2020 /PRNewswire/ -- GT Biopharma, Inc. (OTCQB: GTBP) (GTBP.PA) an immuno-oncology company focused on innovative therapies based on the Company's proprietary NK cell engager (TriKE™) technology platform is pleased to announce the presentation of additional interim data results for the Company's lead therapeutic candidate, GTB-3550, for the treatment of high-risk myelodysplastic syndromes (HR-MDS).\nErica Warlick, M.D, Principal Investigator for the GTB-3550 clinical trial, presented additional clinical data results with the treatment with HR-MDS patient #7 of its TriKE™ GTB-3550 during the Q&A session following her presentation at the 62nd American Society of Hematology (ASH) Annual Meeting and Exposition. Dr. Warlick's HR-MDS patient presentation can be viewed on the GT Biopharma web site at https://ir.gtbiopharma.com/presentations.\nMr. Anthony Cataldo, the Chairman and Chief Executive Officer of GT Biopharma commented, \"Our clinical data demonstrates that our proprietary TriKE™ (CD16/IL15/CD33), safely activated and harnessed the patient's native NK cell's cancer killing ability in a target-directed fashion without side effects. Which is not the case with highly expensive and intrusive supplemental NK cell therapies. We look forward to progressing to the next level.\"\nClinical Benefit Achieved\nPrior to being treated with TriKE™ GTB-3550, the HR-MDS patient failed hypomethylating agent (HMA) and Luspatercept therapies. With TriKE™ GTB-3550 at 50mcg/kg/day (three consecutive 96-hour continuous infusions), the patient achieved a successful bone marrow blast level reduction from 12% before GTB-3550 therapy to 4.6% post GTB-3550 therapy determined by morphological assessment, Additionally, the patient achieved stable hematologic parameters including normal platelet counts throughout therapy. Following this single course of GTB-3550 TriKE™ therapy causing significant reduction in bone marrow blast levels, the patient achieved clinical benefit from GTB-3550 therapy, which qualified patient #7 to receive a hematopoietic stem cell transplant (HSCT). \nNo Toxicities / Potent Native NK Cell Activation and Proliferation achieved without Supplemental NK Cell Therapy\nThe patient exhibited NO SIDE AFFECTS or signs of clinical immune activation, and NO DOSE LIMITING TOXICITY such as cytokine release syndrom...

More updates from Gt Biopharma, Inc.