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GT Biopharma Announces Dosing First Patient In GTB-3550 TriKE(TM) Phase I/II Clinical Trial
TAMPA, FL / ACCESSWIRE / February 26, 2020 / GT Biopharma, Inc. (OTCQB:GTBP)(GTBP.PA) an immuno-oncology company focused on innovative treatments based on the
About this update from Gt Biopharma, Inc.
[{"type":"text","content":"TAMPA, FL / ACCESSWIRE / February 26, 2020 / GT Biopharma, Inc. (OTCQB:GTBP)(GTBP.PA) an immuno-oncology company focused on innovative treatments based on the Company's proprietary NK cell engager (TriKE™) platform announced today that the first patient has been dosed in a Phase I/II clinical trial of its anti-CD16/IL-15/anti-CD33 TriKE™, GTB-3550. The clinical trial is being conducted at the University of Minnesota's Masonic Cancer Center in Minneapolis, Minnesota under the direction of Dr. Erica Warlick.The open-label, dose-escalation Phase I portion of the trial will evaluate GTB-3550 in patients with CD33-expressing, high risk myelodysplastic syndromes, refractory/relapsed acute myeloid leukemia or advanced systemic mastocytosis, and will determine safety and tolerability as well as the pharmacologically active dose and maximum tolerated dose of GTB-3550. The Phase II portion of the trial is planned to further evaluate the recommended dose of GTB-3550 in this patient population.Multiple strategies to redirect immunity have been developed in the past two decades, but they have technical hurdles, cause undesirable side-effects, or are very expensive as exemplified by the T cell therapy-based chimeric antigen receptor (CAR-T) therapies from Bristol-Myers Squibb [NYSE: BMY] and Gilead Sciences [Nasdaq: GILD]). Because TriKE is a targeted immuno-oncology protein-based therapeutic, the cost and patient delivery/administration of TriKE therapy are far superior compared to CAR-T cell therapies.Mr. Anthony Cataldo, the Chairman and Chief Executive Officer of GT Biopharma commented \"we are pleased to have dosed the first patient in our GTB-3550 clinical trial, and thank our investors for helping us achieve this important milestone.\" Mr. Cataldo further stated \"what makes the multi-targeting TriKE ™ unique from all the other single targeting NK cell therapies (Affimed NV [Nasdaq: AFMD], Innate Pharma SA [Nasdaq: IPHA] and Dragonfly Therapeutics [www.dragonflytx.com]) is the proprietary incorporation of IL-15 (an NK cell stimulating cytokine) directly into the core TriKE construct thereby enhancing activation, proliferation and persistence of NK cells while minimizing the toxicities associated with the systemic administration of cytokine therapy to stimulate the patient's immune system.\"About GTB-3550 Trispecific NK cell Engager (Tr...