Press release
Geron Announces First Patient Dosed in Investigator-Led Phase 2 IMpress Trial Evaluating Imetelstat in Patients with Relapsed/Refractory AML or Higher Risk MDS
First clinical trial to explore the potential of imetelstat in relapsed/refractory acute myeloid leukemia (AML) and higher risk myelodysplastic syndromes
About this update from Geron Corporation
[{"type":"text","content":"\n\nFirst clinical trial to explore the potential of imetelstat in relapsed/refractory acute myeloid leukemia (AML) and higher risk myelodysplastic syndromes (MDS)\n\n\n\nData from animal pre-clinical models indicated imetelstat prevented expansion of human AML leukemic stem cells and prolonged survival of mice\n\n\n\n FOSTER CITY, Calif.--(BUSINESS WIRE)--\nGeron Corporation (Nasdaq: GERN), a late-stage clinical biopharmaceutical company, today announced that the first patient has been dosed in the investigator-led Phase 2 IMpress clinical trial evaluating imetelstat, the Company’s first-in-class telomerase inhibitor, in patients with acute myeloid leukemia (AM)L, or higher risk myelodysplastic syndromes (MDS), who are relapsed/refractory/intolerant to hypomethylating agents (HMAs).\n\n\n“This trial is based on multiple preclinical publications that describe the role of telomerase in AML, which have reported that inhibiting telomerase in both mouse and human AML models targets and potentially depletes leukemic stem cells and impairs their leukemic progression,” said Faye Feller, M.D., Executive Vice President, Chief Medical Officer of Geron. “We are delighted that the first patient has been dosed in the investigator-led IMpress Phase 2 study, an important first step to understanding the potential impact of imetelstat in relapsed/refractory AML and higher risk MDS.”\n\n\n“Despite some recent advances in the treatment of AML and higher risk MDS, there is still a tremendous unmet need for new agents, especially in the relapsed/refractory setting,” said Uwe Platzbecker, M.D., Department of Hematology, Cellular Therapy and Hemostaseology, Leipzig University Hospital, Leipzig, Germany, and Principal Investigator of IMpress. “With the first patient dosed and several in screening, we are pleased that IMpress Phase 2 is underway and look forward to understanding more about the potential efficacy of imetelstat in this rather frail and elderly patient population.”\n\n\nAbout IMpress Phase 2\n\n\nIMpress Phase 2 (NCT05583552) is an open-label, single-arm, multicenter study aiming to enroll approximately 45 patients AML and higher risk MDS patients who are relapsed, refractory, or intolerant to HMAs. The objective of this trial is to evaluate the efficacy, in terms of hematologic improvement, of imetelstat in this patient population. The pr...