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GeoVax Announces Peer-Reviewed Publication in NPJ Vaccines of Preclinical Data for Vaccine Candidate Against Marburg Virus Showing 100% Protection
Atlanta, GA, Sept. 03, 2020 (GLOBE NEWSWIRE) -- via NEWMEDIAWIRE -- GeoVax Labs, Inc. (OTCQB: GOVX), a biotechnology company developing human vaccines and
About this update from Geovax Labs, Inc.
[{"type":"text","content":"Atlanta, GA, Sept. 03, 2020 (GLOBE NEWSWIRE) -- via NEWMEDIAWIRE -- GeoVax Labs, Inc. (OTCQB: GOVX), a biotechnology company developing human vaccines and immunotherapies against infectious diseases and cancer, announced today the publication of peer-reviewed data of a new vaccine candidate utilizing the company’s GV-MVA-VLP™ platform against Marburg virus in animal models. The study, based on research conducted in 2019, was published on September 2, 2020 in Nature Partner Journals (NPJ) Vaccines.\n The study demonstrated that guinea pigs vaccinated with GeoVax’s developmental MVA-MARV-VLP vaccine were 100% protected against death and disease caused by the Angola strain of Marburg virus. The vaccine induced immune responses were characterized by Marburg virus-specific binding and neutralizing antibodies. The Angola strain is the most virulent strain of Marburg Virus characterized by up to a 90% fatality rate in humans and a successful vaccination approach is of paramount public health importance. David Dodd, GeoVax President and CEO, commented, “These results demonstrated important progress in the development of our Marburg virus vaccine -- providing a basis for more advanced studies proceeding toward human safety and efficacy trials. We are grateful to Dr. Alexander Bukreyev from the University of Texas Medical Branch and Galveston National Laboratory and his team of investigators for their work in conducting and publishing this research. We look forward to continuing our work in developing this vaccine.” GeoVax’s Modified Vaccinia Ankara (MVA) platform technology is built on a novel MVA vector, with the intended result of producing durable immune responses with the safety characteristics of the replication deficient MVA vector and cost-effective manufacturing system. Importantly, MVA vaccines often elicit protective T cell as well as antibody responses in animals and humans. The GeoVax MVA platform can be combined with the immunogenicity of Virus Like Particles (VLPs) through insertion of multiple antigens from each target pathogen conferring broad protection This strategy expresses proteins in their native conformations, potentially enabling construction of vaccine candidates that can induce protection after a single dose. Single dose protection is a favourable characteristic of preventive vaccines for emerging infectious dis...