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Genprex Announces Sponsored Research Agreement with The University of Michigan Rogel Cancer Center and Lung Cancer Study Collaboration with ALK Positive
Research to Study TUSC2 Combined with ALK-Inhibitors Collaboration with Non-Profit Patient-Focused Research Group Expands Potential Lung Cancer Patient
About this update from Genprex, Inc.
[{"type":"text","content":"Research to Study TUSC2 Combined with ALK-Inhibitors\nCollaboration with Non-Profit Patient-Focused Research Group Expands Potential Lung Cancer Patient Population for Reqorsa® Gene Therapy\nAUSTIN, Texas , Oct. 24, 2024 /PRNewswire/ -- Genprex, Inc. (\"Genprex\" or the \"Company\") (NASDAQ: GNPX), a clinical-stage gene therapy company focused on developing life-changing therapies for patients with cancer and diabetes, today announced the Company has entered into a Sponsored Research Agreement (SRA) with the University of Michigan Rogel Cancer Center to study TUSC2, the tumor suppressor gene used in Genprex's lead drug candidate, Reqorsa® Gene Therapy (quaratusugene ozeplasmid), in combination with ALK-inhibitors in ALK-EML4 positive translocated lung cancer.\n\n \n \n \n \n \n \n\n \nThe Company also announced its collaboration with ALK Positive, a non-profit patient-driven research organization dedicated to improving the life expectancy and quality of life for ALK-positive (ALK+) lung cancer patients. As a part of this collaboration, both Genprex and ALK Positive will share the cost of the SRA with the University of Michigan Rogel Cancer Center.\n\"We are excited to collaborate with the University of Michigan Rogel Cancer Center and ALK Positive, a group that is dedicated to helping patients with this specific subset of lung cancer, to further study how REQORSA in combination with ALK-inhibitors may be a potential therapeutic treatment for ALK+ lung cancer,\" said Ryan Confer, President and Chief Executive Officer at Genprex. \"TUSC2 is often deleted or inactivated in certain types of cancer. Our preclinical data in cell lines with ALK translocations indicate that REQORSA may be effective in combination with ALK inhibitors, and the work in this SRA will build on our earlier studies.\"\nAs the Company further expands its research program to new tumor targets, REQORSA in combination with ALK-inhibitors could be a potential therapeutic treatment for ALK+ lung cancer. TUSC2 is a tumor suppressor gene that is frequently deleted in lung cancer. In fact, approximately 82% of all non-small cell lung cancers (NSCLCs) have decreased amounts of the TUSC2 tumor suppressor protein. ALK translocations are found in approximately 5% of NSCLCs.\nResearch collaborators at the Rogel Cancer Center's Judith Tam ALK Lung Cancer Research Initiative ...