Business
Presentation at European Society of Cardiology
Presentation at European Society of Cardiology.
About this update from Genincode Plc
[{"type":"text","content":"\n\nGENinCode Plc\n(\"GENinCode\" or the \"Company\")\n \nCARDIO inCode® study on risk of incident Coronary Heart Disease\npresented at European Society of Cardiology Annual Meeting in Amsterdam\n \nOxford, UK. GENinCode Plc (AIM: GENI), the polygenics company focused on the prevention of cardiovascular disease, announces the presentation by Kaiser Permanente, US on the 'Utility of the CARDIO inCode-Score® CHD polygenic risk score for incident coronary heart disease interplay with lifestyle in a multi-ethnic cohort of more than 60,000 individuals'. The presentation was made at the Annual Meeting of the European Society of Cardiologists Congress over 25-28 August 2023 in Amsterdam.\n \nThe study investigated over 60,000 adult individuals with no history of Coronary Heart Disease (CHD) from the Genetic Epidemiology Resource in Adult Health and Aging (GERA) multi-ethnic cohort of the Kaiser Permanente Medical Care plan of Northern California, USA. The GERA cohort followed the membership over an average of 14 years, using CARDIO inCode-Score® to assess the polygenic risk of CHD, interplay with lifestyle and the incidence of CHD.\n \nThe study found that genetic and lifestyle factors are independently associated with the incidence of CHD and for individuals with a high polygenic risk measured by CARDIO inCode-Score®, a favourable lifestyle was associated with a 52% lower rate of CHD compared with an unfavourable lifestyle. The study also found that CARDIO inCode-Score® can identify individuals at the highest risk of CHD. These individuals should then be prioritized for lifestyle advice and where appropriate therapeutic intervention as they will benefit the most. By stratifying patients based on their polygenic risk score and targeting treatment to those with the highest risk score, the number of patients needing to be treated to prevent a CHD event were almost halved. CHD 'event' includes: non-fatal AMI, angina and coronary revascularization procedures (coronary by-pass or percutaneous intervention or CHD death. The study confirmed the earlier in life preventative measures can be put in place the lower the future risk underlining the need for 'polygenic risk score' lifetime risk assessment to be used in conjunction with traditional clinical risk assessment.\n \nOther recently announced news\nAs previous...