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Genelux Corporation Announces Publication of Positive Topline Data from Phase 2 VIRO-15 Trial Evaluating Olvimulogene Nanivacirepvec (Olvi-Vec) in Platinum-Resistant or Refractory Ovarian Cancer in the Journal of the American Medical Association (JAMA...
Genelux Corporation Announces Publication of Positive Topline Data from Phase 2 VIRO-15 Trial Evaluating Olvimulogene Nanivacirepvec (Olvi-Vec) in
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[{"type":"text","content":"Genelux Corporation Announces Publication of Positive Topline Data from Phase 2 VIRO-15 Trial Evaluating Olvimulogene Nanivacirepvec (Olvi-Vec) in Platinum-Resistant or Refractory Ovarian Cancer in the Journal of the American Medical Association (JAMA) Oncology \n Phase 2 Trial of Olvi-Vec-primed immunochemotherapy in heavily pre-treated patients Met primary endpoint of objective response rate with deep and durable responsesGenerated promising progression-free survivalDemonstrated clinical reversal of platinum resistance and refractoriness Phase 3 OnPrime/GOG-3076 randomized active-controlled registrational trial in collaboration with GOG Foundation/Partners is currently enrolling The Article was featured on JAMA Oncology’s podcast with lead investigator, Robert W. Holloway, MD WESTLAKE VILLAGE, Calif., May 25, 2023 (GLOBE NEWSWIRE) -- Genelux Corporation (NASDAQ: GNLX), a late clinical-stage immuno-oncology company, today announced the publication of positive topline results from its Phase 2 VIRO-15 trial of Olvi-Vec-primed immunochemotherapy in heavily pretreated patients with platinum-resistant or -refractory ovarian cancer (PRROC) in JAMA Oncology. The article by Holloway et al. was published in print and online and is available here. “We are incredibly pleased to have the Phase 2 trial data featured as an Original Investigation in such a prominent peer-reviewed journal. The results published in JAMA Oncology add to the body of evidence supporting the clinically-meaningful efficacy and safety of Olvi-Vec,\" said Thomas Zindrick, President, Chairman and CEO of Genelux. “Furthermore, we were privileged to have a companion Editorial of our Phase 2 data which we believe further validates the use of our proprietary oncolytic virus in the treatment paradigm of ovarian cancer.” Patients with PRROC have limited therapeutic options, representing a considerable unmet medical need. In this Phase 2 clinical trial of 27 patients [platinum-resistant (n=14) or platinum-refractory (n=13)] and median 4 prior lines of therapy, Olvi-Vec followed by platinum-based chemotherapy ± bevacizumab as immunochemotherapy demonstrated objective response rate (ORR) of 54% and a median progression-free survival (PFS) of 11.0 months with a manageable safety profile. Key Findings All patients completed both Olvi-Vec infusions and chemotherapy. Median follow-...