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GB Sciences Completes and Achieves Statistical Significance in Preclinical Study of Its Proprietary Parkinson's Disease Cannabinoid Formulations and Begins Mechanism of Action Study With the National Research Council of Canada
GB Sciences Completes and Achieves Statistical Significance in Preclinical Study of Its Proprietary Parkinson's Disease Cannabinoid Formulations and Begins Mechanism of Action Study With the National Research Council of Canada.
About this update from Gb Sciences, Inc.
[{"type":"text","content":"LAS VEGAS / ACCESSWIRE / April 6, 2020 / GB Sciences, Inc. (OTCQB:GBLX), is pleased to announce that the company's Canadian entity, GBS Global Biopharma, Inc. (GBS), signed an Amendment to their Agreement with the National Research Council of Canada (NRC). The NRC has demonstrated that the company's PD formulations were able to reduce behavioral changes associated with the loss of dopamine-producing neurons, which underlies the pathology of Parkinson's disease in the animal model. Based on achieving the statistically significant reduction in Parkinson's disease symptomology, GBS has signed an amendment to include a final phase of testing, which will study the mechanism of action for these promising formulations. These important preclinical results will be included in GBS' Investigational New Drug (IND) application with US FDA in order to enter human clinical trial as early as this year. New therapies to address Parkinson's disease symptoms are needed to help those afflicted with this debilitating disease. The combined direct and indirect costs associated with Parkinson's disease are estimated at $52 billion in the U.S. alone."We have expanded the scope of testing with the NRC for our Parkinson's formulations based on achieving the statistically significant reduction in Parkinson's disease symptomology faster than expected," explained Dr. Andrea Small-Howard, Chief Science Officer and Director of both GB Sciences, Inc. and GBS Global Biopharma, Inc. "The NRC lab in Halifax has improved upon a zebrafish model of Parkinson's disease that allows us to rapidly validate our PD formulas and efficiently optimize them. Unlike rodent models of PD that take months to run with just a few animals in each treatment group, the zebrafish model of Parkinson's disease is a high throughput system. Each experiment takes about a week to complete and each treatment group has a minimum of twenty-five individuals, which makes statistical significance easier to reach quickly. Not only does the zebrafish model provide symptomatic data, we can also use this model to address the mechanism for how our formulas might be able to provide relief to Parkinson's patients. At the NRC, they can directly measure the loss or protection of the dopamine-producing neurons in response to our PD formulas. They...