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Galmed Reports Significant Anti-Fibrotic Effects of Aramchol in a Lung Fibrosis Model
Statistically significant clinical and histology improvements were also demonstrated in a model of inflammatory bowel disease (IBD)Data reinforcing the
About this update from Galmed Pharmaceuticals Ltd.
[{"type":"text","content":"Statistically significant clinical and histology improvements were also demonstrated in a model of inflammatory bowel disease (IBD)Data reinforcing the expansion of Aramchol's Clinical Development to Additional Indications TEL AVIV, Israel, July 7, 2022 /PRNewswire/ -- Galmed Pharmaceuticals Ltd. (Nasdaq: GLMD) (\"Galmed\" or the \"Company\"), a clinical-stage biopharmaceutical company for liver, metabolic, fibrosis and inflammatory diseases, announced today results showing significant effects of Aramchol in pre-clinical model of both lung and gastrointestinal (GI) fibrosis.\nFibrosis is a common complication of chronic inflammation and can affect all organs and tissues. To date, only limited anti-fibrotic drugs are approved or are in development, most of which have restricting side effects. Aramchol is a partial inhibitor of SCD1 with distinctive, direct, anti-fibrotic activity demonstrated in several pre-clinical models.\nTreatment with Aramchol resulted in statistically significant fibrosis improvement in a validated bleomycin model of lung fibrosis (IPF), comparable to Pirfenidone which is the gold standard treatment. Findings were seen across all important indicators for the severity of fibrosis including hydroxyproline (a marker for collagen deposition in the fibrotic tissue) P\nStatistically significant improvements were also demonstrated in a validated DSS model of inflammatory bowel disease (IBD). Dextran sulfate sodium (DSS) induced colitis model is widely used because of its similarities with human ulcerative colitis. Clinical improvements were statistically significant at least by p value < 0.05 while in histological score (based on inflammation and colon structural changes) significance was as low as p","length":2411,"tagName":"div"}]