Business
eXoZymes Advancing Commercial Readiness With Profound Production Metrics on Initial NCT Pilot Run
N-trans-caffeoyltyramine (NCT) is an interesting naturally occurring compound that has attracted scientific attention in exploratory studies related to lipid metabolism and energy utilization pathways. The production was executed by an external partner ...
About this update from Exozymes Inc.
[{"type":"list","items":[{"val":[{"type":"text","content":"N-trans-caffeoyltyramine (NCT) is an interesting naturally occurring compound that has attracted scientific attention in exploratory studies related to lipid metabolism and energy utilization pathways.","length":201,"tagName":"p"}]},{"val":[{"type":"text","content":"The production was executed by an external partner under pilot-scale conditions using standardized protocols.","length":109,"tagName":"p"}]},{"val":[{"type":"text","content":"The pilot run achieved approximately 99% reaction conversion, 90% isolated yield, and 535 grams of NCT at 99.6% pharma-grade purity.","length":132,"tagName":"p"}]},{"val":[{"type":"text","content":"Reaction performance was observed to improve at increased operating scale.","length":74,"tagName":"p"}]},{"val":[{"type":"text","content":"High-purity NCT now available for formulation development with commercial partners.","length":83,"tagName":"p"}]}],"tagName":"ul","bulletedList":true,"length":599,"olType":false},{"type":"text","content":"LOS ANGELES, CA / ACCESS Newswire / January 29, 2026 / Today, eXoZymes Inc. (NASDAQ:EXOZ) ("eXoZymes") - a pioneer of AI-enhanced enzymes that can transform sustainable feedstock into nutraceuticals and new medicines - reported detailed downstream performance results from its recently completed 100-liter pilot production run of NCT. The results expand upon the previously announced 100× scale-up milestone and provide new data demonstrating manufacturability, material recovery, and product quality at commercially relevant scale.","length":542,"tagName":"p"},{"type":"text","content":"Following completion of the pilot run and product isolation and purification, eXoZymes achieved approximately 99% reaction conversion, 91% process- recovery, and a 90% isolated yield, resulting in 535 grams of isolated NCT. Final product purity was measured at 99.6%, based on post-isolation analytical characterization. Together, these metrics provide a full, end-to-end view of process performance spanning reaction, isolation, and purification.","length":447,"tagName":"p"},{"type":"text","content":""What makes this initial NCT pilot run profound is how counter to conventional experience these results are. In most biological systems, performance typically degrades as you scale - reactions become harder to control, yields drop, and variability ...