eXoZymes Achieves 100× Scale-up of NCT Production Using Exozymes, Demonstrating Near-perfect Feedstock Conversion

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[{"type":"text","content":"LOS ANGELES, CALIFORNIA / ACCESS Newswire / December 11, 2025 / Today, eXoZymes Inc. (NASDAQ:EXOZ) ("eXoZymes") - a pioneer of AI-enhanced enzymes that can transform sustainable feedstock into nutraceuticals and new medicines - announced the successful achievement of a 100-fold scale-up of its N-trans-caffeoyltyramine (NCT) production process using its proprietary exozyme-based, cell-free biomanufacturing platform. This effort, with a conversion level of over 99% from feedstock to product, marks a major milestone in the scalability of the exozymes platform.","length":573,"tagName":"p"},{"type":"text","content":""Scaling a complex biocatalytic reaction by 100× while sustaining high feedstock conversion strengthens our belief that exozymes will form the foundation of the next generation of biomanufacturing," said Michael Heltzen, CEO of eXoZymes. "We're very enthusiastic about this progress and see it as an important inflection point in demonstrating that cell-free, enzyme-driven systems can be engineered to operate reliably at scale. This truly opens the door to producing molecules that have historically been constrained by traditional manufacturing approaches."","length":584,"tagName":"p"},{"type":"text","content":"The scaled reaction maintained exceptionally high conversion efficiency, demonstrating near-complete transformation of input feedstock into target product under large-volume operating conditions. This performance confirms that the exozyme-driven process not only scales linearly but can match - or exceed - conversion levels observed at smaller scales. The batch production was executed using standardized protocols under partner-operated conditions by Cayman Chemical, underscoring the robustness, transferability, and scalability of the process and technology.","length":562,"tagName":"p"},{"type":"text","content":"Dr. Tyler Korman, CSO of eXoZymes, adds, "Scaling while preserving reaction performance has historically been challenging, and this outcome supports the growing body of evidence that cell-free enzyme production pathways - aka exozymes systems - can overcome fundamental limitations associated with traditional biomanufacturing approaches. Achieving over 99% conversion at scale is a significant validation of our exozyme biosolution - both from a scientific as well as a commerc...

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