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Opdivo® (nivolumab) in Combination with CABOMETYX® (cabozantinib) Demonstrates Continued Survival Benefits with Over Two Years of Follow-Up in the CheckMate -9ER Trial in First-Line Advanced Renal Cell Carcinoma
Updated results to be presented at ASCO GU 2022 show sustained efficacy benefits with Opdivo in combination with CABOMETYX compared to sunitinib Patients
About this update from Exelixis, Inc.
[{"type":"text","content":"\nUpdated results to be presented at ASCO GU 2022 show sustained efficacy benefits with Opdivo in combination with CABOMETYX compared to sunitinib\n\nPatients treated with Opdivo and CABOMETYX continue to report improvements in health-related quality of life in a separate analysis\n\n PRINCETON, N.J. & ALAMEDA, Calif.--(BUSINESS WIRE)--\nToday Bristol Myers Squibb (NYSE: BMY) and Exelixis, Inc. (NASDAQ: EXEL) announced two-year (25.4 months minimum; 32.9 months median) follow-up results from analyses of the Phase 3 CheckMate -9ER trial, demonstrating sustained survival and response rate benefits, as well as health-related quality of life (HRQoL) improvements, with the combination of Opdivo® (nivolumab) and CABOMETYX® (cabozantinib) versus sunitinib in the first-line treatment of advanced renal cell carcinoma (RCC). These updated results will be featured in two poster presentations at the American Society of Clinical Oncology (ASCO) 2022 Genitourinary Cancers Symposium from February 17-19, 2022.\n\n“The new data from CheckMate -9ER evaluating nivolumab and cabozantinib are significant for patients with first-line advanced renal cell carcinoma, as they provide further evidence of efficacy benefits as well as favorable patient-reported quality of life outcomes with this combination,” said Toni Choueiri, M.D., Director of the Lank Center for Genitourinary Oncology at Dana-Farber Cancer Institute and Jerome and Nancy Kohlberg Professor of Medicine at Harvard Medical School. “As clinicians, we are constantly looking for therapies that can help more patients control their disease without reporting a detriment in their quality of life.”\n\nAbstract #350: Final overall survival analysis and organ-specific target lesion assessments with 2-year follow-up in CheckMate 9ER: nivolumab plus cabozantinib vs sunitinib for patients with advanced renal cell carcinoma (Powles, et. al.)\n\nWith median follow-up of 32.9 months (25.4 months minimum), Opdivo in combination with CABOMETYX (n=323) continued to show superior overall survival (OS), progression-free survival (PFS), objective response rates (ORR), duration of response (DoR) and complete response (CR) rates compared to sunitinib (n=328). No new safety signals emerged with extended follow-up. In the full study population:\n\n\nOS: At the final OS analysis, Opdivo in combination with CABOMETYX ...