Esperion Announces Pooled Analysis from Phase 3 LDL-C Lowering Clinical Development Program of NEXLETOL™ (Bempedoic Acid) Tablets Presented at the American Diabetes Association 80th Scientific Sessions

ANN ARBOR, Mich., June 14, 2020 (GLOBE NEWSWIRE) -- Esperion (NASDAQ: ESPR) today announced that pooled analysis from four Phase 3 clinical studies of NEXLETOL were presented at the American Diabetes Association 80th Scientific Sessions.  According to the American Diabetes Association (ADA) guidelines, elevated LDL cholesterol is a common problem for people with diabetes. Also referred to as hyperlipidemia, this condition greatly increases the risk of developing cardiovascular disease.

The presentation, titled “Efficacy and Safety of Bempedoic acid in Patients with Diabetes, Prediabetes, and Normoglycemia: Analysis of Pooled Patient-Level Data From 4 Phase 3 Clinical Trials” was delivered by Lawrence A. Leiter, MD, FRCPC, FACP, FACE, FAHA Director of the Lipid Clinic at St. Michael's Hospital and Professor of Medicine and Nutritional Sciences, University of Toronto.

The presentation demonstrated that patients treated with NEXLETOL experienced a significant lowering of LDL-Cholesterol compared with placebo in all glycemic status subgroups.  Similarly, the analysis also showed that NEXLETOL significantly lowered total cholesterol, non-HDL-C, Apo B and hsCRP across all subgroups.  Importantly, NEXLETOL did not worsen measurements of glycemic control or increase the occurrence of new-onset diabetes compared with placebo.  In patients with diabetes (n=1,135), the analysis highlighted that NEXLETOL significantly reduced hemoglobin A1c (HbA1c) by 0.19% versus placebo at 12 weeks (p