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Erasca Announces Issuance of a U.S. Patent Covering Pan-RAS Molecular Glue ERAS-0015
The issued patent provides intellectual property protection for ERAS-0015 and related compositions until at least 2043 Initial Phase 1 monotherapy data for
About this update from Erasca, Inc.
[{"type":"text","content":"The issued patent provides intellectual property protection for ERAS-0015 and related compositions until at least 2043 Initial Phase 1 monotherapy data for ERAS-0015 and pan-KRAS inhibitor ERAS-4001 expected in 2026 SAN DIEGO, Nov. 06, 2025 (GLOBE NEWSWIRE) -- Erasca, Inc. (Nasdaq: ERAS), a clinical-stage precision oncology company singularly focused on discovering, developing, and commercializing therapies for patients with RAS/MAPK pathway-driven cancers, today announced that the U.S. Patent and Trademark Office has issued Patent No. 12,458,647, titled “Macrocyclic Derivative And Use Thereof.” The patent claims protect the composition of matter for Erasca’s potentially best-in-class pan-RAS molecular glue ERAS-0015 and related compositions until September 2043, which may be subject to patent term adjustments or extensions affording even later protection. “This U.S. patent is a foundational milestone for our ERAS-0015 program, further highlighting our efficient execution across this program since its in-licensing in May 2024,” said Jonathan E. Lim, M.D., Erasca’s chairman, CEO, and co-founder. “Covering ERAS-0015 until at least 2043, this patent is among a series of patent filings designed to form a strong and durable intellectual property portfolio for our RAS-targeting franchise. We look forward to initial Phase 1 monotherapy data for ERAS-0015 and pan-KRAS inhibitor ERAS-4001, both of which are expected in 2026.” About ERAS-0015ERAS-0015 is an oral, highly potent pan-RAS molecular glue that is designed to inhibit RAS signaling with a potential best-in-class profile. In preclinical studies, ERAS-0015 demonstrated approximately 8-21 times higher binding affinity to cyclophilin A (CypA) versus the most-advanced pan-RAS molecular glue in development, approximately 5 times greater potency in RAS inhibition, and greater in vivo antitumor activity evidenced by achieving comparable or greater tumor growth inhibition or regression at doses that are as low as approximately one-tenth to one-fifth the dose of the most-advanced pan-RAS molecular glue. ERAS-0015 is also designed to prevent resistance against mutant-selective inhibitors through inhibition of RAS wildtype variants. In addition, ERAS-0015 has demonstrated favorable absorption, distribution, metabolism, and excretion (ADME) and pharmacokinetic (PK) properties in multiple anim...