Business
Equillium Reports Fourth Quarter and Full Year 2021 Financial Results and Provides Corporate & Clinical Development Updates
Announced positive topline data from EQUATE study of itolizumab in first-line aGVHD Initiated EQUATOR Phase 3 study of itolizumab in first-line aGVHD
About this update from Equillium, Inc.
[{"type":"text","content":"\nAnnounced positive topline data from EQUATE study of itolizumab in first-line aGVHD\n\nInitiated EQUATOR Phase 3 study of itolizumab in first-line aGVHD\n\nPresented interim safety data and reduction in proteinuria from the EQUALISE study of itolizumab in lupus patients\n\nAcquired Bioniz Therapeutics, adding two first-in-class clinical-stage assets to pipeline and proprietary product discovery platform\n\n LA JOLLA, Calif.--(BUSINESS WIRE)--\nEquillium, Inc. (Nasdaq: EQ), a clinical-stage biotechnology company focused on developing novel therapeutics to treat severe autoimmune and inflammatory disorders with high unmet medical need, today announced financial results for the fourth quarter and full year 2021 and provided corporate and clinical development updates.\n\n“I’m proud of our team and the progress we have made since the beginning of last year,” said Bruce Steel, chief executive officer at Equillium. “In that short time, we have announced data from multiple clinical studies, strengthened our balance sheet with a direct investment from Decheng Capital, added two experienced members to our board of directors, and most recently completed the acquisition of Bioniz Therapeutics. Perhaps most exciting is what is still to come, as this acquisition expands our pipeline of first-in-class therapeutic candidates that have the potential to improve patient care and adds significantly to our future operational milestones and pending data catalysts.”\n\n“Our clinical advancements were fueled initially by itolizumab, our novel monoclonal antibody that selectively targets the CD6-ALCAM pathway,” said Steve Connelly, chief scientific officer at Equillium. “Data from the EQUATE study in first-line acute graft-versus-host disease demonstrated continued positive and durable clinical responses in a severely ill patient population, leading us to our Phase 3 study initiated earlier this month. The versatility and potential therapeutic utility of itolizumab was also demonstrated in interim data from the Type A portion of the Phase 1b EQUALISE study in patients with systemic lupus erythematosus showing a decline in proteinuria in a subset of patients with elevated urinary protein. The addition of two first-in-class clinical-stage assets and a proprietary product discovery platform from Bioniz transforms Equillium into a multi-asset company as w...