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Equillium Announces Publication of Data in the Journal of Clinical Investigation Highlighting the Importance of the CD6-ALCAM Pathway in the Pathogenesis of Lupus Nephritis
First data to demonstrate the contribution of CD6-ALCAM and T-cells to the pathogenesis of lupus nephritis Largest, most comprehensive cohort of lupus
About this update from Equillium, Inc.
[{"type":"text","content":"\nFirst data to demonstrate the contribution of CD6-ALCAM and T-cells to the pathogenesis of lupus nephritis\n\nLargest, most comprehensive cohort of lupus nephritis patients analyzed to date supports soluble ALCAM as a biomarker for disease activity\n\n LA JOLLA, Calif.--(BUSINESS WIRE)--\nEquillium, Inc. (Nasdaq: EQ), a clinical-stage biotechnology company developing itolizumab to treat severe autoimmune and inflammatory disorders with high unmet medical need, today announced publication of a manuscript featured on the front cover of the Journal of Clinical Investigation (www.jci.org), confirming the role of T cells activated by the CD6-ALCAM pathway in the development of lupus nephritis (LN). The newly published data supports Equillium’s research of itolizumab, a first-in-class anti-CD6 monoclonal antibody that targets the CD6-ALCAM signaling pathway to selectively inhibit pathogenic T effector cells. Equillium is currently evaluating itolizumab in LN patients in the EQUALISE study (NCTT04128579).\n\nThe Journal of Clinical Investigation is the premier venue for discoveries in basic and clinical biomedical science that will advance the practice of medicine. The publication, titled “The CD6-ALCAM pathway promotes lupus nephritis via T cell mediated responses,” was the result of a collaborative study between investigators from The Accelerated Medicines Partnership (AMP), Chaim Putterman, M.D., (Albert Einstein College of Medicine), Chandra Mohan, M.D., Ph.D., (University of Houston) and Equillium. The work demonstrates the association of soluble urinary ALCAM (uALCAM) with human disease and how modulating the CD6-ALCAM pathway in animal models significantly reduces disease pathology.\n\n“More targeted therapies are urgently needed to effectively treat LN, as well as other T cell mediated diseases,” said Dr. Putterman. “This study, using urine biomarkers, tissue biopsy data and animal models, conclusively demonstrates that the CD6-ALCAM pathway is important in the pathogenesis of this disease, and supports the targeting of this pathway using itolizumab in the EQUALISE study.”\n\nBuilding on work first reported by Professor Chandra Mohan, this study examined uALCAM in an extended cross-sectional cohort of 1038 patients of different ethnicities with LN and systemic lupus erythematosus (SLE). These results validate uALCAM as a biom...