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Equillium Announces Presentation at the 3rd Annual Cytokine-Based Drug Development Summit
LA JOLLA, Calif.--(BUSINESS WIRE)-- Equillium, Inc. (Nasdaq: EQ), a clinical-stage biotechnology company focused on developing novel therapeutics to treat
About this update from Equillium, Inc.
[{"type":"text","content":" LA JOLLA, Calif.--(BUSINESS WIRE)--\nEquillium, Inc. (Nasdaq: EQ), a clinical-stage biotechnology company focused on developing novel therapeutics to treat severe autoimmune and inflammatory disorders with high unmet medical need, today announced a presentation at the 3rd Annual Cytokine-Based Drug Development Summit. The presentation highlights Equillium’s multi-cytokine inhibitor technology and platform, and applications of cytokine technology beyond oncology. Data on the platform, including the lead tri-specific inhibitory agent, EQ101, were presented by Dr. Stephen Connelly, co-founder and chief scientific officer of Equillium. The Summit is taking place at the Wyndham Boston Beacon Hill and runs July 26 – 29.\n\n“Cytokines play a critical role in inflammation, autoimmunity and cancer, and modulating their activity has become central to how we think about developing innovative treatments for these diseases,” said Dr. Connelly. “This Summit is a great forum to showcase the pre-clinical, translational and clinical data supporting EQ101 a novel, first-in-class tri-specific cytokine inhibitor in the treatment of neoplastic and inflammatory skin diseases. This data also provides translational support for our upcoming clinical catalysts: a planned Phase 2 clinical study of EQ101 in alopecia areata and a Phase 1 SAD/MAD study of EQ102 – a novel first-in-class bi-specific cytokine inhibitor – in normal healthy volunteers, as well as celiac disease patients. Both studies are scheduled to commence later this year.”\n\nThe presentation, titled “Targeting Biological Synergy At the Receptor Level – Multi-specific\n\nCytokine Inhibitors”, focuses on the design and development of multi-specific cytokine inhibitors and the importance of targeting biological synergy to optimize therapeutic outcomes. Validation of this approach is demonstrated with EQ101, a novel, first-in-class tri-specific cytokine inhibitor that can selectively target and potently inhibit the key common yc family cytokines of IL-2, IL-9 and IL-15. Translational studies have shown that EQ101 inhibits these cytokines and exhibits potent activity in suppressing multiple lymphoproliferative or leukemic T-cell lines. Furthermore, clinical efficacy and a favorable safety profile has been demonstrated in patients with refractory cutaneous T cell lymphoma. In addition to applicat...