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Equillium Announces Oral Presentation Highlighting Positive Data from the EQUATE Study in Acute Graft-Versus-Host Disease at the EHA2021 Virtual Congress of the European Hematology Association
LA JOLLA, Calif., May 13, 2021 (GLOBE NEWSWIRE) -- Equillium, Inc. (Nasdaq: EQ), a clinical-stage biotechnology company developing itolizumab to treat severe
About this update from Equillium, Inc.
[{"type":"text","content":"LA JOLLA, Calif., May 13, 2021 (GLOBE NEWSWIRE) -- Equillium, Inc. (Nasdaq: EQ), a clinical-stage biotechnology company developing itolizumab to treat severe autoimmune and inflammatory disorders, today announced that an abstract highlighting positive data from the EQUATE study of itolizumab in acute graft-versus-host disease (aGVHD) has been accepted for oral presentation at EHA2021 Virtual Congress. The annual meeting of the European Hematology Association will be held virtually June 9 – 17, 2021. The abstract describes results from the ongoing Phase 1b EQUATE study of itolizumab in combination with steroids for the first-line treatment of patients with aGVHD. The primary cohorts enrolled 10 patients with Grade III-IV aGVHD that received itolizumab within 72 hours of first steroid dose, whereas the expansion cohorts also include subjects with Grade II aGVHD and an Ann Arbor Score of 2 or 3 that received itolizumab within 7 days of first steroid dose. The company will present data on all patient cohorts in the EQUATE study. The benefit-risk profile observed support continued evaluation in future randomized controlled trials. Title: Interim results from the EQUATE Study: Preliminary safety and efficacy of itolizumab, a novel targeted anti-CD6 therapy, newly diagnosed acute graft-versus-host diseaseFirst Author: John Koreth – Dana Farber Cancer Institute, Harvard Medical SchoolPresentation Session: Stem cell transplantation - GvHDDate and Time: Friday, June 11, 3:00 am ET Abstract Code: S238 About Graft-Versus-Host Disease (GVHD)GVHD is a multisystem disorder that is a common complication of allogeneic hematopoietic stem cell transplants (allo-HSCT) caused by the transplanted immune system recognizing and attacking the recipient’s body. Symptoms of GVHD include rash, itching, skin discoloration, nausea, vomiting, diarrhea, and jaundice, as well as eye dryness and irritation. GVHD is the leading cause of non-relapse mortality in cancer patients receiving allo-HSCT, and its risk limits the number and type of patients receiving HSCT. GVHD results in high morbidity and mortality, with five-year survival of approximately 53% in patients who respond to steroid treatment and mortality as high as 95% in patients who do not respond to steroids. There are no approved treatments for first-line aGVHD. Published literature (MacMillan et al., ...