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Enveric Biosciences Announces Two Poster Presentations at the Canadian Chemistry Conference and Exhibition (CSC 2023)
CAMBRIDGE, Mass.--(BUSINESS WIRE)-- Enveric Biosciences, Inc. (NASDAQ: ENVB) (“Enveric” or the “Company”), a biotechnology company dedicated to the
About this update from Enveric Biosciences, Inc.
[{"type":"text","content":" CAMBRIDGE, Mass.--(BUSINESS WIRE)--\nEnveric Biosciences, Inc. (NASDAQ: ENVB) (“Enveric” or the “Company”), a biotechnology company dedicated to the development of novel small-molecule therapeutics for the treatment of anxiety, depression, and addiction disorders, today announced that its research involving the synthesis of small molecule derivatives of psychoactive compounds has been featured in two poster presentations at the Canadian Chemistry Conference and Exhibition (CSC 2023) being held in Vancouver June 4-8, 2023.\n\n\nThe first poster titled, “Novel psilocin prodrugs with altered pharmacological properties as candidate therapies for treatment-resistant anxiety disorders,” describes the chemical synthesis of Enveric’s EVM201 Series molecules to identify novel prodrugs of psilocin with altered metabolic profiles and reduced pharmacological exposure aimed at reducing the duration of the psychedelic experience. Beginning with 30 unique molecules, representing nine distinct prodrug classes, 15 candidates were selected that released the highest levels of psilocin in vitro. Pharmacokinetic analysis confirmed that the efficient release of psilocin in vitro correlated with the amount of psilocin detected in blood plasma. Two molecules that produced plasma psilocin concentrations comparable or superior to psilocybin were evaluated for long-term anxiolytic benefit in chronically stressed mice using the marble-burying psychiatric model.\n\n\nThe second poster titled, “Design, synthesis and pharmacological evaluation of novel MDMA derivatives as potential therapies for the treatment of psychiatric conditions,” describes the design and chemical synthesis of a library of 30 novel MDMA (Ecstasy) derivatives. The compounds were tested for their ability to bind serotonin receptors and transporters. The results show how modifications to the chemical structure of MDMA can lead to substantial alteration in binding to different serotonin receptors and transporters, which could alter pharmacological properties.\n\n\n“The two posters presented at CSC 2023 showcase the pioneering work of our researchers and collaborators, who are using cutting-edge techniques to produce novel therapeutic candidates that harness key properties of known psychoactive compounds but are designed to display safer pharmacologic profiles more applicable in the mental ...