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Imara to Report Data Demonstrating the Potential of Tovinontrine (IMR-687) for the Treatment of Heart Failure with Preserved Ejection Fraction (HFpEF)
Preclinical data from three different mouse models of HFpEF to be presented at American Heart Association (AHA) Scientific Sessions HFpEF development to be
About this update from Enliven Therapeutics, Inc.
[{"type":"text","content":"Preclinical data from three different mouse models of HFpEF to be presented at American Heart Association (AHA) Scientific Sessions HFpEF development to be led by cardiologist Toni Bransford, M.D., FACC, FASE Imara’s new Vice President of Clinical Development BOSTON, Nov. 08, 2021 (GLOBE NEWSWIRE) -- Imara Inc. (Nasdaq: IMRA), a clinical-stage biopharmaceutical company dedicated to developing and commercializing novel therapeutics to treat patients suffering from rare inherited genetic disorders of hemoglobin and other serious diseases, announced data today in three preclinical mouse models of heart failure with preserved ejection fraction (HFpEF) treated with tovinontrine (IMR-687). Selective inhibition of phosphodiesterase-9 (PDE9) with tovinontrine was shown to be effective for prevention and treatment of cardiac hypertrophy and renal dysfunction, indicating that tovinontrine may be a promising treatment option for patients suffering from HFpEF. Imara also announced the appointment of Toni Bransford, M.D., as Vice President of Clinical Development, with responsibilities that include leading the design and execution of a Phase 2 proof-of-concept study in HFpEF. Dr. Bransford holds extensive experience leading clinical development of cardiovascular therapies and specifically HFpEF studies. “The data from our pre-clinical models in concert with published literature regarding the role of PDE9 in heart failure suggest that tovinontrine has potential as a treatment for HFpEF,” said Deepak Gupta, M.D., M.S.C.I, Assistant Professor of Medicine at Vanderbilt University Medical Center’s Division of Cardiovascular Medicine. “In three distinct mouse models of HFpEF, compared with control mice, tovinontrine was shown to not only reduce the median size of cardiomyocytes, but also lower plasma B-type and atrial natriuretic peptide levels. Moreover, markers of renal dysfunction, including blood urea nitrogen and urine albumin-to-creatinine ratio, were lower in mice treated with tovinontrine compared with vehicle treated mice in all models. Notably, tovinontrine did not significantly change heart rate or blood pressure. Overall, the results and safety profile in preclinical models of HFpEF are encouraging for the advancement of this program into the clinic.” “We are excited about extending our footprint into HFpEF with what we believe is a be...