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Magenta Therapeutics Announces Updated Phase 2 Data on MGTA-456 Cell Therapy, Demonstrating Continued Durability in Inherited Metabolic Disorders
-- Additional data from Phase 2 study show that MGTA-456 demonstrates clinically meaningful durable benefits for patients with inherited metabolic disorders
About this update from Dianthus Therapeutics, Inc.
[{"type":"text","content":"\n-- Additional data from Phase 2 study show that MGTA-456 demonstrates clinically meaningful durable benefits for patients with inherited metabolic disorders one year following treatment –\n\n\n-- Magenta intends to complete enrollment in Phase 2 in 2020 and continue dialogue with the FDA under the RMAT designation on design of a registration-enabling study, and to have discussions with the European Medicines Agency for development in Europe as well –\n\n CAMBRIDGE, Mass.--(BUSINESS WIRE)--\nMagenta Therapeutics (NASDAQ: MGTA), a clinical-stage biotechnology company developing novel medicines to bring the curative power of immune reset to more patients, today announced updated clinical data from Phase 2 trials of its cell therapy, MGTA-456, at the Transplant and Cellular Therapy (TCT) Annual Meeting in Orlando, Florida. New results from Magenta’s MGTA-117 conditioning program and MGTA-145 stem cell mobilization program will be presented at TCT later this week.\n\n\nMGTA-456 is a cell therapy designed to provide a high dose of hematopoietic stem cells (HSCs) that are well matched to the patient to enable safe immune and blood system rebuild in IMD patients and remission in patients with blood cancers. Magenta is currently developing MGTA-456 in an ongoing Phase 2 study in patients with inherited metabolic disorders (IMD), including cerebral adrenoleukodystrophy (cALD), mucopolysaccharidosis type IH (MPS I, or Hurler syndrome), metachromatic leukodystrophy (MLD) or globoid cell leukodystrophy (GLD, or Krabbe disease). These are rare, rapidly progressive neurologic disorders that are fatal when left untreated. Investigators at the University of Minnesota are also studying the cryopreserved formulation of MGTA-456 in a Phase 2 clinical trial in patients with high-risk blood cancers.\n\n\n“The clinical demonstration of rapid and durable resolution of disease in patients with inherited metabolic disorders is very compelling; it’s particularly encouraging as these results are not seen with currently available treatments, nor with gene therapies under investigation,” said John Davis, MD, MPH, Chief Medical Officer, Magenta Therapeutics. “Data from the University of Minnesota study in blood cancers add to the body of safety and engraftment data for MGTA-456, and, importantly, validate the introduction of cryopreserved 456 product into t...