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Magenta Therapeutics Announces Collaboration with the National Marrow Donor Program/Be The Match to Advance Development of MGTA-145 for First-Line Mobilization of Stem Cells from Healthy Donors and Subsequent Patient Transplant
Collaboration focuses on clinical development of MGTA-145 for stem cell mobilization in allogeneic transplant in patients with blood cancers Plan to initiate
About this update from Dianthus Therapeutics, Inc.
[{"type":"text","content":"\nCollaboration focuses on clinical development of MGTA-145 for stem cell mobilization in allogeneic transplant in patients with blood cancers\n\n\nPlan to initiate a Phase II trial of MGTA-145 in matched related donors for patients undergoing allogeneic transplant\n\n CAMBRIDGE, Mass. & MINNEAPOLIS--(BUSINESS WIRE)--\nMagenta Therapeutics (Nasdaq: MGTA) and the National Marrow Donor Program® (NMDP)/Be The Match®, the global leader in providing a cure to patients with life-threatening blood and marrow cancers like leukemia, lymphoma and other diseases, today announced a clinical collaboration agreement to evaluate the potential utility of MGTA-145, Magenta’s investigational first-line stem cell mobilization program, for mobilizing and collecting hematopoietic stem cells from donors in a single day and then using them for allogeneic transplants in patients. This life-saving procedure is currently used in approximately 28,000 patients in the U.S. and Europe each year, but approximately 62,000 additional eligible patients do not receive an allogeneic transplant due to challenges, including difficulty with the donation process.\n\n\nUnder the collaboration, Magenta and NMDP/Be The Match will run a Phase 2 clinical trial of MGTA-145 to mobilize and collect hematopoietic stem cells from donors which will then be transplanted into patients with blood cancers in need of a stem cell transplant. The number of stem cells mobilized, engraftment function and benefit to disease will be measured. Magenta will retain all commercial rights to MGTA-145.\n\n\nMGTA-145, a CXCR2 agonist, works in combination with plerixafor, a CXCR4 antagonist, to harness the physiological mechanism of stem cell mobilization into peripheral blood. MGTA-145 achieved all of the safety and activity endpoints in the recently completed Phase 1 trials in over 100 volunteers. Results showed that MGTA-145, in combination with plerixafor, enabled safe, same-day dosing, mobilization and collection of superior functional hematopoietic stem cells for transplant compared to the current standard of care.\n\n\nThe NMDP/Be The Match is the leading stem cell transplant organization in the United States and facilitates more than 6,500 stem cell transplants per year, through its contracted global network of 187 transplant centers. Through Be The Match BioTherapies®, the company also p...