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Denali Therapeutics Announces Progression and Expansion of Broad Therapeutic Portfolio for Neurodegeneration and Expected Key Milestones in 2022
Key data readouts to include additional Phase 1/2 data on DNL310 (ETV:IDS) in MPS II (Hunter syndrome) and the first clinical data on DNL919 (ATV:TREM2), both
About this update from Denali Therapeutics Inc.
[{"type":"text","content":"Key data readouts to include additional Phase 1/2 data on DNL310 (ETV:IDS) in MPS II (Hunter syndrome) and the first clinical data on DNL919 (ATV:TREM2), both potentially further validating Denali’s Transport Vehicle (TV) platform; in addition, first Phase 1b data in ALS on DNL343, Denali’s small molecule eIF2B activatorCommencing late-stage clinical trials designed to potentially support registration for DNL310 (ETV:IDS) in MPS II and LRRK2 inhibitor BIIB122 (DNL151) in Parkinson’s disease RIPK1 inhibitors partnered with Sanofi advancing with multiple Phase 2 clinical trials, including SAR443820 (DNL788) in ALS and SAR443122 (DNL758) in cutaneous lupus erythematosus (CLE), with additional indications plannedAnnouncing Takeda has exercised its option to co-develop and co-commercialize DNL919 (ATV:TREM2) in Alzheimer’s disease making this the second TV-enabled program partnered with Takeda in addition to DNL593 (PTV:PGRN) in frontotemporal dementia-granulin (FTD-GRN)Announcing new data that further expand the scope of the TV platform, including the first nonhuman primate data with Oligonucleotide Transport Vehicle (OTV), preclinical biomarker data with the second Enzyme Transport Vehicle (ETV) program, DNL126 (ETV:SGSH), and bispecific ATV:HER2 with improved preclinical efficacy and brain uptake as compared to non-ATV HER2 antibodies SOUTH SAN FRANCISCO, Calif., Jan. 10, 2022 (GLOBE NEWSWIRE) -- Denali Therapeutics Inc. (NASDAQ: DNLI), a biopharmaceutical company developing a broad portfolio of product candidates engineered to cross the blood-brain barrier (BBB) for neurodegenerative diseases, today announced program progress and expected milestones for 2022, which Chief Executive Officer, Ryan Watts, Ph.D., will highlight during a corporate presentation at the 40th Annual J.P. Morgan Healthcare Conference on Tuesday, January 11, at 11:15 a.m. Eastern Time. “We are looking forward to a high impact year in 2022, having accomplished several clinical and regulatory milestones in 2021 as well as further validation of our TV platform for delivery of biotherapeutics to the brain,” said Dr. Watts. “We are well positioned to deliver in 2022 with our dedicated team, our BBB-crossing platforms and our diversified portfolio of Denali owned and strategically partnered assets. We continue to build our clinical manufacturing and commercial cap...