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Cullinan Oncology to Present New Preclinical Data for CLN-619 and CLN-617 at the 2023 American Association for Cancer Research Annual Meeting
CLN-619 is a MICA/B directed humanized IgG1 antibody being studied in a global Phase 1 clinical trial in patients with advanced solid tumors. Initial clinical
About this update from Cullinan Therapeutics, Inc.
[{"type":"text","content":"CLN-619 is a MICA/B directed humanized IgG1 antibody being studied in a global Phase 1 clinical trial in patients with advanced solid tumors. Initial clinical data from the ongoing trial is on-track to be released mid-2023. CLN-617 is a cytokine therapy combining IL-2 and IL-12 in a single molecule. An Investigational New Drug Application was recently submitted to the FDA for CLN-617. CAMBRIDGE, Mass., March 14, 2023 (GLOBE NEWSWIRE) -- Cullinan Oncology, Inc., (Nasdaq: CGEM) (“Cullinan Oncology”) a biopharmaceutical company focused on modality-agnostic targeted oncology therapies, today announced that posters of preclinical data highlighting the therapeutic potential of two assets, CLN-619 and CLN-617, will be presented at the 2023 American Association for Cancer Research (AACR) Annual Meeting taking place in Orlando, Florida, April 14-17, 2023. Details of the Cullinan Oncology posters at AACR are as follows: Poster Title: The Structural Basis for Inhibition of MICA Shedding and Anti-Tumor Activity of the Monoclonal Anti-MICA/B Antibody, CLN-619Session: Therapeutic Antibodies 2Session Date/Time: Monday, April 17, 2023, 1:30 pm – 5 pm ETLocation: Poster Section 23Abstract Number: 2943Poster Board Number: 21Authors: Kerry A. Whalen, Naveen K. Mehta, Kristan Meetze, Jennifer S. Michaelson, Patrick A. Baeuerle Poster Title: CLN-617 is a First-in-Class Fusion Protein That Retains IL-2 and IL-12 in the Injected Tumor and Potently Triggers Systemic Anti-Tumor ImmunitySession: Immunomodulatory Agents and Interventions 2Session Date/Time: Monday, April 17, 2023, 9 am – 12:30 pm ETLocation: Poster Section 24Abstract Number: 1839Poster Board Number: 11Authors: Naveen K. Mehta, Kavya Rakhra, Kristan Meetze, K. Dane Wittrup, Jennifer S. Michaelson, Patrick A. Baeuerle “We are proud to present data at this year’s AACR conference for two programs in our diverse and robust pipeline, CLN-619 which is a MICA/B directed IgG1 antibody and CLN-617, an IL-2 and IL-12 cytokine therapy,” said Dr. Patrick Baeuerle, Chief Scientific Officer, Cullinan Oncology. “While distinct programs, each has the potential to be a first- and/or best-in-class therapy across a broad range of solid tumor types. We are excited to present more data on these two programs in poster presentations at AACR 2023 and highlight the strides we are making toward creating new standar...