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CStone Announces Publication of GEMSTONE-303 Study Results for Sugemalimab (Cejemly®) in JAMA
CStone Pharmaceuticals ("CStone", HKEX: 2616), an innovation-driven biopharmaceutical company focused on the research and development of anti-cancer therapies, today announced the publication of the GEMSTONE-303 study results for sugemalimab (brand name: Cejemly®) in the prestigious Journal of the American Medical Association (JAMA) .
About this update from Cstone Pharmaceuticals
[{"type":"list","items":[{"val":[{"type":"text","content":"Sugemalimab is the world's first anti-PD-L1 monoclonal antibody approved for the treatment of gastric or gastroesophageal junction (G/GEJ) adenocarcinoma. The GEMSTONE-303 study results support sugemalimab in combination with chemotherapy as a new standard first-line treatment for patients with PD-L1 combined positive score (CPS) ≥5. ","length":344,"tagName":"p"}]},{"val":[{"type":"text","content":"Sugemalimab is the first anti-PD-L1 monoclonal antibody demonstrating superior overall survival (OS) and progression free survival (PFS) with a manageable safety profile in combination with chemotherapy compared to placebo plus chemotherapy in patients with locally advanced or metastatic G/GEJ adenocarcinoma who have not received prior systemic treatment for advanced disease and have PD-L1 CPS ≥5.","length":405,"tagName":"p"}]},{"val":[{"type":"text","content":"Sugemalimab has received approvals for five indications in China, and for first-line treatment of Stage IV non-small cell lung cancer (NSCLC) in China, Europe and the UK. CStone will continue to engage with health authorities in Europe and other regions for regulatory expansion.","length":279,"tagName":"p"}]}],"tagName":"ul","bulletedList":true,"length":1028,"olType":false},{"type":"text","content":"SUZHOU, China, Feb. 24, 2025 /PRNewswire/ -- CStone Pharmaceuticals ("CStone", HKEX: 2616), an innovation-driven biopharmaceutical company focused on the research and development of anti-cancer therapies, today announced the publication of the GEMSTONE-303 study results for sugemalimab (brand name: Cejemly®) in the prestigious Journal of the American Medical Association (JAMA) .","length":401,"tagName":"p"},{"type":"text","content":"GEMSTONE-303 is a Phase 3, randomized, double-blind, placebo-controlled study designed to evaluate the efficacy of sugemalimab in combination with capecitabine and oxaliplatin (CAPOX) compared to placebo plus CAPOX as first-line treatment for patients with unresectable locally advanced or metastatic G/GEJ adenocarcinoma with PD-L1 CPS ≥5. The dual primary endpoints were OS and investigator-assessed PFS. Key secondary endpoints included PFS assessed by the Blinded Independent Central Review Committee (BICR), objective response rate (ORR), and duration of response (DoR).","length":580,"...