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Additional Analyses of CRN04894 Preclinical and Phase 1 Results to be Presented at the 10th International Congress of Neuroendocrinology
SAN DIEGO, Aug. 04, 2022 (GLOBE NEWSWIRE) -- Crinetics Pharmaceuticals, Inc. (Nasdaq: CRNX) today announced that Peter J. Trainer, M.D., vice president of
About this update from Crinetics Pharmaceuticals, Inc.
[{"type":"text","content":"SAN DIEGO, Aug. 04, 2022 (GLOBE NEWSWIRE) -- Crinetics Pharmaceuticals, Inc. (Nasdaq: CRNX) today announced that Peter J. Trainer, M.D., vice president of clinical endocrinology, will review additional analyses from the preclinical and Phase 1 clinical studies of CRN04894 in an oral presentation at the 10th International Congress of Neuroendocrinology (ICN), being held August 7-10, 2022. CRN04894 is an investigational, oral, small molecule adrenocorticotropic hormone (ACTH) antagonist that is being developed by Crinetics for the treatment of Cushing’s disease, congenital adrenal hyperplasia (CAH) and other conditions of excess ACTH. Data from the first-in-human Phase 1 study demonstrated pharmacologic proof-of-concept for CRN04894, as treatment led to reductions in both serum cortisol levels and 24-hour urine free cortisol excretion in the presence of sustained, disease-like ACTH concentrations. Additional details on the upcoming presentation are shown below. Title: CRN04894 an oral, nonpeptide ACTH receptor antagonist reverses ACTH-stimulated glucocorticoid secretion in rodents and humansDate/Time: August 10, 2022 at 9:00 - 10:40 a.m. BSTSession: Stress Pathology and Emerging TherapiesConference Location: Scottish Event Campus, Glasgow, Scotland Additional details on the presentation session including the presentation abstract can be accessed here. The presentation will be made available on the Crinetics website in accordance with the congress’ embargo policy. About the CRN04894 Phase 1 StudyThe double-blind, randomized, placebo-controlled first-in-human study enrolled 88 healthy volunteers who were divided into multiple cohorts in the single ascending dose (n=39) and multiple ascending dose (n=49) portions of the study. In both portions of the study, safety and pharmacokinetics were assessed. In addition, pharmacodynamic responses were evaluated before and after challenges with injected synthetic ACTH to assess pharmacologic effects resulting from exposure to CRN04894. About CRN04894Adrenocorticotropic hormone (ACTH) is synthesized and secreted by the pituitary gland and selectively binds to its receptor melanocortin type 2 receptor (MC2R), which is selectively expressed in the adrenal gland. This interaction of ACTH with MCR2 activates the adrenal and results in production of cortisol, a stress hormone that is involved in the...