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Coya Therapeutics to Present Biomarker and Preliminary Efficacy Clinical Data for COYA 301 for the Treatment of Patients with Alzheimer’s Disease (AD) at the 2023 Keystone Symposia Meeting for Neurodegeneration held on May 15-19th, 2023
- The proof-of-concept open-label study evaluated the safety and tolerability, regulatory T cell (Treg) function, blood biomarkers, and preliminary efficacy
About this update from Coya Therapeutics, Inc.
[{"type":"text","content":"\n- The proof-of-concept open-label study evaluated the safety and tolerability, regulatory T cell (Treg) function, blood biomarkers, and preliminary efficacy of COYA 301 in eight patients with mild-to-moderate AD. The academic study was conducted by Dr. Appel and Dr. Faridar at the Houston Methodist Hospital.\n\n- COYA 301 is Coya’s investigational low-dose interleukin-2 (IL-2) for subcutaneous administration. COYA 301 has been designed to enhance Treg anti-inflammatory function in vivo.\n\n- Treg dysfunction has been identified as a key driver of neuroinflammation, which is observed in AD and other neurodegenerative diseases, and may contribute to disease progression.\n\n HOUSTON--(BUSINESS WIRE)--\nCoya Therapeutics, Inc. (NASDAQ: COYA) (“Coya” or the “Company”), a clinical-stage biotechnology company developing multiple therapeutic platforms intended to enhance Treg function, today announced the presentation of results from an academic clinical study in patients with Alzheimer’s Disease (AD) with Coya’s COYA 301, its proprietary investigational proprietary biologic. The presentation will be made at the 2023 Keystone Symposia Neurodegeneration: New Biology Guiding the Next Generation of Therapeutic Development, to be held at Whistler, British Columbia, Canada from May 15-19th, 2023.\n\nThe proof-of-concept open-label clinical study is the first-of-its-kind evaluating low-dose IL-2 immunotherapy for the treatment of AD. Patients in the study received investigational treatment with COYA 301 for four consecutive months and were evaluated for safety and tolerability, Treg function, serum biomarkers of inflammation, and clinical functioning as measured by the Mini-Mental State Examination (MMSE) and the Clinical Dementia Rating (CDR). COYA 301 is intended to enhance anti-inflammatory regulatory T cell function in vivo and has been designed to be administered subcutaneously to minimize treatment burden for patients and caregivers.\n\nThe study was conducted at the Houston Methodist Research Institute (Houston, Texas) and led by Stanley Appel, M.D. and Alireza Faridar, M.D. Dr. Appel is chair of Coya’s Scientific Advisory Board and is former chair of the Stanley H. Appel Department of Neurology. He is the director of the Ann Kimball & John W. Johnson Center for Cellular Therapeutics, Professor of Neurology at Weill Cornell Medical C...