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Coya Therapeutics Reports Additional Blood Biomarker and Brain Imaging Data Showing Decrease in Neuroinflammation Following Treatment with COYA 301 in Alzheimer’s Disease (AD)
Coya reports new data illustrating that administration of COYA 301 (low dose Interleukin-2 (IL-2)) in an open- label study in 8 patients with mild to
About this update from Coya Therapeutics, Inc.
[{"type":"text","content":"\n\nCoya reports new data illustrating that administration of COYA 301 (low dose Interleukin-2 (IL-2)) in an open- label study in 8 patients with mild to moderate AD (COYA 301 Trial) resulted in a statistically significant reduction in the expression of three well characterized proinflammatory cytokines -- Tumor Necrosis Factor alpha (TNF-α), Interleukin 6 (IL-6), and Interleukin 1- Beta (IL-1β) -- which correlated with lack of cognitive decline of the patients over the course of the study.\n\n\n\nTNF-α is one of the main inflammatory cytokines involved in initiating and propagating an inflammatory response and its role in the pathophysiology of AD has been documented. The proinflammatory cytokines IL-6 and IL-1β have also been documented to play a central role in AD and in the development of neuroinflammation and induction of neuronal damage.\n\n\n\nFurthermore, Coya reports a case study of a patient in the COYA 301 trial who had pre-treatment and post-treatment Positron Emission Tomography (PET) brain scans to evaluate neuroinflammation. Meaningful reductions in neuroinflammation were observed throughout the cerebral cortex including hippocampal regions following treatment with COYA 301, which correlated with improvement in cognitive function in this patient.\n\n\n\nCoya previously reported that patients in the COYA 301 trial achieved a statistically significant improvement in cognitive function, as measured by the Mini-Mental State Examination test (MMSE) and no cognitive decline when measured by the Alzheimer’s Disease Assessment Scale–Cognitive Subscale (ADAS-Cog), and the Clinical Dementia Rating-Sum of Boxes scale (CDR-SB).\n\n\n\nCoya also previously reported that treatment with COYA 301 restored peripheral Treg function and numbers, significantly lowered the levels of systemic chemokines CCL11, CCL2, and cytokine IL-15, and was well tolerated.\n\n\n\nAn ongoing academic phase 2 double blind randomized trial (supported by the Gates Foundation and Alzheimer’s Association) for use of low dose IL-2 in up to 46 mild to moderate AD patients that is underway at Houston Methodist (led by Alireza Faridar M.D. and the Chair of Coya’s SAB, Stanley Appel, M.D.), should report top line data in Q2 2024, and inform Coya on its strategy.\n\n\n\n HOUSTON--(BUSINESS WIRE)--\nCoya Therapeutics, Inc. (NASDAQ: COYA) (“Coya” or the “Company”...