Business
Coya Therapeutics Expands Pipeline and Intellectual Property Portfolio with Filing of New U.S. Patents for COYA 301 in Combination with Glucagon-Like Peptide-1 (GLP-1) Receptor Agonists
Combination of COYA 301 + GLP-1 receptor agonists (GLP-1 RA) may present a promising multi-pathway targeted approach for additive and/or synergistic
About this update from Coya Therapeutics, Inc.
[{"type":"text","content":"\nCombination of COYA 301 + GLP-1 receptor agonists (GLP-1 RA) may present a promising multi-pathway targeted approach for additive and/or synergistic anti-inflammatory functions for the potential treatment of inflammatory diseases, including neurodegenerative, autoimmune, and metabolic conditions;\n\n\nData supporting these patents indicate that COYA 301 and GLP-1 RA combinations may have an additive and/or synergistic anti-inflammatory effect on multiple cell types, including enhancement of regulatory T cell function, suppression of pro-inflammatory myeloid and T cells, and repolarization of these cells to anti-inflammatory phenotypes;\n\n\nProposed proprietary combinations will expand Coya’s pipeline and has potential to expand the GLP-1 market beyond the approved indications of diabetes and obesity, while opening the door to strategic partnerships and scientific collaborations\n\n\n HOUSTON--(BUSINESS WIRE)--\nCoya Therapeutics, Inc. (NASDAQ: COYA) (“Coya” or the “Company”), a clinical-stage biotechnology company developing biologics intended to enhance regulatory T cell (Treg) function, announces the filing of intellectual property protection for the combination of COYA 301, or recombinant human low dose interleukin-2 (LD IL-2), and Glucagon-Like Peptide-1 receptor agonists (GLP-1 RAs).\n\n\nDr. Arun Swaminathan, Coya’s Chief Business Officer, stated, “There has been an upswing in interest from major pharma companies looking to expand their GLP-1 RA pipeline including testing combination mechanistic approaches. The combination of low-dose IL-2 with GLP-1 RAs could offer a differentiated approach to addressing multiple conditions, including in neurodegenerative conditions such as Alzheimer’s Disease, in which GLP-1 RAs have recently shown promise. We believe the potential of this proprietary combination could lead to value-creating business development partnerships.”\n\n\nThere has been extensive commercial success using the GLP-1 RA class for the treatment of diabetes and obesity. GLP-1 RAs have anti-inflammatory and anti-oxidant effects that may contribute to their overall glucose-lowering benefits. The influence of GLP-1 RAs on inflammatory pathways provides an opportunity to optimize these effects by combining with LD IL-2 mediated Treg enhancement.\n\n\nGLP-1 RAs and LD IL-2 act through distinct mechanisms of action to ...