Press release
Compass Therapeutics Announces Presentation on CTX-8371, A Bispecific Antibody Targeting PD-1 and PD-L1, at the 2022 AACR Annual Meeting in New Orleans
BOSTON, March 30, 2022 (GLOBE NEWSWIRE) -- Compass Therapeutics Inc. (Nasdaq: CMPX), a clinical-stage, oncology-focused biotechnology company developing
About this update from Compass Therapeutics, Inc.
[{"type":"text","content":"BOSTON, March 30, 2022 (GLOBE NEWSWIRE) -- Compass Therapeutics Inc. (Nasdaq: CMPX), a clinical-stage, oncology-focused biotechnology company developing proprietary antibody-based therapeutics to treat multiple human diseases, announced today that it will present preclinical data on CTX-8371, a next generation bispecific checkpoint inhibitor that simultaneously targets PD-1 and PD-L1 at the upcoming American Association for Cancer Research (AACR) Annual Meeting, which is being held April 8-13, 2022, at the Ernest N. Morial Convention Center in New Orleans, Louisiana. Presentation Details: Title: Dose Range Finding Study in Non-human Primates Confirms the Unique Mechanism of Action of CTX-8371, a Novel Bispecific Antibody Blocking PD-1 and PD-L1 Abstract Number: 5027 Session Title: Combination Immunotherapies / Therapeutic Antibodies Presenter: Diana Albu, Ph.D. Date/Time: Tuesday, April 12, 2022; 1:30 pm to 5:00 pm ET Location: Poster Section 32 About CTX-8371 CTX-8371 is a bispecific antibody that simultaneously targets the programmed death receptor (PD-1) and the programmed death receptor ligand (PD-L1) that are expressed on immune cells and cancer cells respectively. CTX-8371 is currently undergoing IND-enabling preclinical development. In pre-clinical studies, CTX-8371 demonstrated enhanced anti-tumor activity compared to multiple commercially available monoclonal antibodies targeting PD-1 or PD-L1 across several solid tumor animal models, including large syngeneic tumors as well as immunologically resistant melanoma metastasis models. Investigation into the molecular mechanism of action (MOA) of CTX-8371 showed that simultaneous binding of CTX-8371 to PD-1 and PD-L1 resulted in both cell-to-cell bridging and sustainable shedding of the extra-cellular domain of PD-1 from the surface of effector cells. This unique MOA indicates that CTX-8371 has the potential to eliminate PD-1 from the surface of effector cells rather than transiently reducing the ability of PD-1 to bind to its ligands, thus providing sustainable relief of immune suppression, which may explain the observed enhanced activity of CTX-8371 over commercially available anti-PD-1 and anti-PD-L1 monoclonal antibodies. Effectively, it appears that CTX-8371 converts PD-1-positive cells into PD-1-negative cells. About Compass Therapeutics Compass Therapeutics, Inc. is a...