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CollPlant, Tel Aviv University and Sheba Medical Center Join Forces to Co-Develop rhCollagen-Based 3D Bioprinted Human Intestine Model for Drug Discovery and Personalized Treatment of Ulcerative Colitis
Agreement to accelerate development of a 'Gut-on-a-Chip' tissue model to improve therapeutic choice and outcome of ulcerative colitis patients CollPlant to
About this update from Collplant Biotechnologies Ltd.
[{"type":"text","content":"Agreement to accelerate development of a 'Gut-on-a-Chip' tissue model to improve therapeutic choice and outcome of ulcerative colitis patients CollPlant to fund development and receive exclusive license to manufacture and commercialize human intestine tissue modelIntestine model highlights vast application possibilities for rhCollagen and CollPlant's strategic expansion into personalized medicine, an emerging approach for disease treatmentREHOVOT, Israel, Nov. 15, 2022 /PRNewswire/ -- CollPlant (NASDAQ: CLGN), a regenerative and aesthetic medicine company developing innovative human collagen-based technologies and products, together with Ramot, the Technology Transfer Company of Tel Aviv University and Sheba Medical Center, a hospital ranked by Newsweek magazine as one of the Top 10 world best hospitals for the 4th consecutive year (2019-2022), today announced entering into a license and research agreement to co-develop a 'Gut-on-a-Chip' tissue model for drug discovery and high throughput screening of drugs. The model is intended to be used in personal medicine applications for the treatment of ulcerative colitis, an inflammatory bowel disease affecting millions of individuals worldwide. The in-vitro intestine-on-chip platform combines CollPlant's human recombinant collagen (rhCollagen) with other proprietary biomaterials and human cells. Designed to emulate the human intestine tissue, the 3D bioprinted model will allow medical professionals to identify drug targets and personalized therapeutic responses that can lead to improved patient outcomes.\n\n \n \n \n \n \n \n\n \nThe collaboration draws upon CollPlant's expertise in high precision 3D bioprinting and collagen-based bioinks for scalable and reproducible biofabrication of human tissues, with Tel Aviv University's 'smart' Organ-on-a-Chip platform and Sheba Medical Center's capabilities in advanced treatment screening. The co-development is led by Dr. Ben Maoz from Tel Aviv University, who completed his post-doctoral fellowship under the supervision of Prof. Don Ingber and Prof. Kit Parker at the Wyss Institute at Harvard University, Dr. Yael Haberman from the Pediatric Gastroenterology unit of Sheba Medical Center, and CollPlant's team of scientists and engineers. Under the terms of the agreement, CollPlant will fund the development of the intestine model and receive an ex...