Business
First Participant Dosed in Europe as Cognition Therapeutics Expand Phase 2 Alzheimer's Disease Clinical Trial of Oral CT1812
SHINE Study Expanded from USA to Include sites in Spain, the Netherlands, and Czech Republic PURCHASE, N.Y., Dec. 15, 2022 (GLOBE NEWSWIRE) -- Cognition
About this update from Cognition Therapeutics, Inc.
[{"type":"text","content":"SHINE Study Expanded from USA to Include sites in Spain, the Netherlands, and Czech Republic\nPURCHASE, N.Y., Dec. 15, 2022 (GLOBE NEWSWIRE) -- Cognition Therapeutics, Inc. (Nasdaq: CGTX) (the “Company” or “Cognition”), announced that the Phase 2 SHINE clinical trial of CT1812, an experimental oral, once-daily capsule in development for mild-to-moderate Alzheimer’s disease, has been expanded into clinical sites in Spain, the Netherlands, and the Czech Republic. CT1812 is designed to modulate a key cellular receptor known as sigma-2 and block oligomers from binding to neurons, thus preventing their synaptotoxic effects. This new mechanism of action is fundamentally distinct from and complementary with that of anti-amyloid antibody-based immunotherapy, such as lecanemab. The Brain Research Center Amsterdam in The Netherlands is the first European site to enroll participants in the Phase 2 SHINE study being conducted in approximately 144 individuals. Dr. Niels Prins, director of the Center stated, “We are committed to offering Alzheimer’s patients and their families access to innovative clinical trials, such as the SHINE study of CT1812. With our industry partners, we believe we can make inroads in development of new medicines to slow the progression of Alzheimer’s and related disorders.” Anthony O. Caggiano, M.D., Ph.D., Cognition’s chief medical officer and head of R&D added, “We believe that the approach of targeting soluble oligomeric Aβ species has been validated by lecanemab findings announced earlier this year by Eisai and Biogen at CTAD 2022. However, unlike antibodies, which lower brain amyloid levels, CT1812 was designed to shield neurons from these toxic proteins.” Results from initial trials with CT1812 provided evidence to support expansion of the clinical programs. In particular, positive trends were seen in cognition, MRI volumetric imaging and proteomic biomarkers: Slower decline in ADAS-cog vs placebo over six monthsPreservation of brain volume (composite) vs placebo with statistically significant (p","length":2662,"tagName":"div"}]