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Cognition Therapeutics to Present Analysis Showing Impact of CT1812 on Pathways Implicated in Dry Age-related Macular Degeneration at ARVO 2023
NEW YORK, April 19, 2023 (GLOBE NEWSWIRE) -- Cognition Therapeutics, Inc. (NASDAQ: CGTX) will be presenting in vitro results characterizing the role of
About this update from Cognition Therapeutics, Inc.
[{"type":"text","content":"NEW YORK, April 19, 2023 (GLOBE NEWSWIRE) -- Cognition Therapeutics, Inc. (NASDAQ: CGTX) will be presenting in vitro results characterizing the role of sigma-2 (σ-2) receptors and effect of CT1812 in cell-based models of dry age-related macular degeneration (AMD). CT1812 is an experimental orally delivered, small molecule drug candidate that binds to σ-2 receptors, which have been shown to regulate key cellular processes involved in age-related degenerative diseases. In these in vitro studies, cultures of retinal pigment epithelial (RPE) cells derived from induced pluripotent stem cells (iPSC) as well as cultures of ARPE-19 cells, a cell line of naturally occurring RPEs, were subjected to conditions that lead to cellular dysfunction in dry AMD. Biological pathways impacted by disease-relevant stressors in RPE cells were identified, some of which were also modulated by CT1812. Pathways that were impacted by CT1812 include those involved in immune response, extracellular matrix remodeling and RPE cell survival. A detailed poster presentation (poster #C0072) describing the results and their impact on our understanding of the σ-2 receptor’s role in dry AMD and the progression of geographic atrophy (GA) will be made at the upcoming meeting of the Association for Research in Vision and Ophthalmology (ARVO) being held in New Orleans from April 23-27. Poster details:Title: Unbiased Transcriptomic Analysis of the sigma-2 Modulator, CT1812 in Cell-based Models of Dry Age-related Macular DegenerationAuthors: Lizama B, Waybright L, Malagise E, Watto E, Caggiano AO, Hamby MEPoster Session: March 24, 2023 at 3:15pm CT In addition, the company will be hosting a booth (#1351) during the meeting where additional information will be made available on the company’s planned Phase 2 program in dry AMD. About CT1812CT1812 is an experimental orally delivered small molecule sigma-2 (σ-2) receptor modulator. Cognition received FDA clearance to commence a Phase 2 clinical trial of CT1812 in participants with geographic atrophy (GA) secondary to dry age-related macular degeneration. Clinical site selection in the Phase 2 MAGNIFY study is underway. CT1812 is also in development for mild-to-moderate Alzheimer’s disease in the Phase 2 SHINE study (NCT03507790) and dementia with Lewy bodies in the Phase 2 SHIMMER study (NCT05225415). CT1812 penetrates the blo...