Business
Cognition Therapeutics Reports Financial Results for the Second Quarter 2024 and Provides Business and Clinical Update
- Proof-of-Concept Phase 2 SHINE Trial Demonstrates ~40% Mean Improvement in ADAS-Cog 11 vs Placebo and Consistent Positive Changes Across Multiple Cognitive
About this update from Cognition Therapeutics, Inc.
[{"type":"text","content":"- Proof-of-Concept Phase 2 SHINE Trial Demonstrates ~40% Mean Improvement in ADAS-Cog 11 vs Placebo and Consistent Positive Changes Across Multiple Cognitive and Functional Measures - - On Track to Report Topline Results from SHIMMER Study in Mild-to-Moderate DLB by YE 2024 - - Company to Host Investor Conference Call at 8:30 a.m. - PURCHASE, N.Y., Aug. 08, 2024 (GLOBE NEWSWIRE) -- Cognition Therapeutics, Inc. (Nasdaq: CGTX), a clinical stage company developing product candidates that treat neurodegenerative disorders, (the “Company” or “Cognition”), today reported financial results for the second quarter ended June 30, 2024, and provided a business update. “We announced favorable results from the Phase 2 ‘SHINE’ Study that provided proof-of-concept that CT1812 has potential to slow the progression of mild-to-moderate Alzheimer’s disease after just six months of treatment,” said Lisa Ricciardi, Cognition’s president and CEO. “In terms of next steps, we are looking forward to reading out results from our ‘SHIMMER’ study in mild-to-moderate dementia with Lewy bodies by year-end 2024 and are now planning the next phase of development in our Alzheimer's disease program.” Business and Corporate Highlights Phase 2 proof-of-concept SHINE study (NCT03507790) of CT1812 in 153 participants with mild-to-moderate Alzheimer’s disease demonstrated consistent positive changes slowing cognitive decline, a biomarker signal of neuroprotection, and a favorable safety and tolerability profile Participants treated with once daily oral CT1812 (pooled 100 and 300mg) experienced a 39% slowing of decline compared to placebo-treated as measured with ADAS-Cog 11*Consistent trends favoring CT1812 were observed in other cognitive measures: ADAS-Cog 13, cognitive composite, MMSE; and in functional measures: ADCS-ADL and ADCS-CGICA significant reduction in neurofilament light chain (NfL), a biomarker of neurodegeneration, in participants treated with 300mg CT1812 compared to placeboNo discontinuations due to AEs in the 100mg CT1812 group; all elevated liver enzymes occurring in the 300 mg dose group; serious adverse events (SAE) similar in placebo and treated armsResults presented at the 2024 Alzheimer’s Association International Conference (AAIC) Investor webcast held to discuss SHINE results, an archive of which is available here.Published three manuscripts...