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Cognition Therapeutics and the Alzheimer's Clinical Trials Consortium Initiate First Clinical Site in the Phase 2 START Study in Early Alzheimer’s Disease
NEW YORK, July 05, 2023 (GLOBE NEWSWIRE) -- Cognition Therapeutics, Inc. (NASDAQ: CGTX) announced that the first clinical trial site has been activated and
About this update from Cognition Therapeutics, Inc.
[{"type":"text","content":"NEW YORK, July 05, 2023 (GLOBE NEWSWIRE) -- Cognition Therapeutics, Inc. (NASDAQ: CGTX) announced that the first clinical trial site has been activated and can begin recruiting participants for the 540-patient Phase 2 START study of CT1812 in adults with early Alzheimer’s disease. The University of Kentucky Sanders-Brown Center on Aging (SBCoA) is the first of approximately 50 sites in North America that has been activated by the Alzheimer's Clinical Trials Consortium (ACTC). The ACTC, founded in 2018 with funding from the National Institute on Aging (NIA), part of the National Institutes of Health, is one of the NIA’s largest public-private partnerships. “Our START study represents a unique and important opportunity for Cognition to study CT1812 in people with early Alzheimer's disease,” added Cognition president and CEO, Lisa Ricciardi. While trials in this patient population are crucial, the long treatment period required to show a change in cognition can be overly burdensome for small biotechnology companies. Without the support of the ACTC and the NIA's $81 million grant, we would likely not be in a position to offer these research participants the opportunity to test an oral once-daily medication that may slow the progression of Alzheimer's disease. It is incredibly exciting and humbling to have reached the stage where patient recruitment can finally begin.” The randomized placebo-controlled START trial is being conducted at approximately 50 sites in North America including over 30 premier academic institutions that are part of the ACTC network. An estimated 540 adults with early Alzheimer’s disease (MMSE 20-30) who have elevated beta amyloid (Aβ) will be randomized to receive once-daily oral CT1812 or placebo for 18 months. CT1812 is an investigational oral, small molecule designed to bind to a receptor on synapses and prevent the toxic effects of soluble Aβ oligomers on neurons. “The hard work from our dedicated team of clinical program managers, statisticians, biomarker experts, and recruitment, retention and diversity leaders has paid off with the activation of the site at the SBCoA,” concluded Paul Aisen, M.D., professor of neurology at the University of Southern California and director of the Alzheimer's Therapeutic Research Institute. “We’re looking forward to partnering with the team at SBCoA and other investigator...