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Codexis Presents Pre-Clinical Data Highlighting Gene Therapy Programs at the ASGCT 25th Annual Meeting
REDWOOD CITY, Calif., May 16, 2022 (GLOBE NEWSWIRE) -- Codexis, Inc. (NASDAQ: CDXS), a leading enzyme engineering company enabling the promise of synthetic
About this update from Codexis, Inc.
[{"type":"text","content":"REDWOOD CITY, Calif., May 16, 2022 (GLOBE NEWSWIRE) -- Codexis, Inc. (NASDAQ: CDXS), a leading enzyme engineering company enabling the promise of synthetic biology, today announced that three of its gene therapy programs are the subject of two poster presentations at the American Society of Gene and Cell Therapy (ASGCT) 25th Annual Meeting, taking place from May 16 to May 19, 2022, in Washington, D.C. and virtually. The pre-clinical data highlights enzyme variants engineered with Codexis’ CodeEvolver® platform to offer potentially improved efficacy as compared to current enzymes when administered as transgenes in gene therapies for Hemophilia A, Fabry Disease, and Pompe Disease. “The exciting results coming out of our early-stage programs across Hemophilia A, Fabry Disease, and Pompe Disease showcase the promise of engineered enzyme variants to inspire a new generation of gene therapies with improved stability and expression profiles,” said John Nicols, Codexis President and CEO. “With our unique CodeEvolver® platform, our scientists efficiently perform structure-functions analyses on tens of thousands of variants and generate transgenes that encode superior enzymes, thereby overcoming the therapeutic shortcomings of naturally occurring sequences used in current therapies. When applied to gene therapies, this process holds great potential for addressing unmet needs and improving patient outcomes, and we look forward to further advancing these programs as we work to harness the untapped potential of directed evolution.” The Company’s first poster, titled, “Towards Improving the Treatment of Hemophilia A with Directed Evolution of the Factor VIII Transgene,” highlights the potential of engineered transgenes to offer improved efficacy of Recombinant Factor VIII (FVIII) therapies in patients with Hemophilia A. Codexis used CodeEvolver® to identify variants of a B-domain deleted FVIII (FVIII-BDD) with superior properties as compared to the wild-type enzyme. These characteristics include enhanced expression, secretion, stability, cofactor potency, and reduced immunogenicity, which could improve upon current gene therapy strategies by potentially enabling lower doses and achieving higher quality patient outcomes. Engineered FVIII-BDD variants were shown to retain more than 80% of their activity after four days, as opposed to wild-type ...