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Clene Announces Peer-Reviewed Publication Describing CNM-Au8 Catalytic Neuroprotective Mechanism of Action
Novel catalytic mechanism of CNM-Au8 reveals its promise as a versatile new treatment to address multiple assaults on neuronal health in neurodegenerative
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[{"type":"text","content":"Novel catalytic mechanism of CNM-Au8 reveals its promise as a versatile new treatment to address multiple assaults on neuronal health in neurodegenerative diseases SALT LAKE CITY, Sept. 28, 2023 (GLOBE NEWSWIRE) -- Clene Inc. (Nasdaq: CLNN) through its wholly owned subsidiary Clene Nanomedicine Inc. (collectively, “Clene”), today announced the publication of a scientific paper describing the catalytic mechanism of action of its investigational drug CNM-Au8® in the journal Small, a top nanotechnology-focused journal at the interface of materials science, chemistry, physics, engineering, medicine, and biology. The publication, titled “A Mechanism Underpinning the Bioenergetic Metabolism-Regulating Function of Gold Nanocatalysts,” is co-authored by lead investigators at the University of South Carolina and Clene. This study demonstrates that the robust neuroprotective properties of CNM-Au8 can be attributed to its therapeutic catalytic activity. When neurons were exposed to toxins that induce neuronal death, CNM-Au8 treatment promoted the survival of cells and preservation of neurite networks. To unravel the mechanisms underpinning the neuroprotective function of CNM-Au8, Professor Hui Wang, Ph.D., and his graduate students at the University of South Carolina conducted detailed studies focused on characterizing CNM-Au8-mediated catalytic reactions to determine how CNM-Au8 effectively regulates cellular health and metabolism. Neuronal deficiencies have been associated with cell death in multiple types of neurodegenerative disease, as documented by a growing body of scientific literature. Because of the unique mechanism of CNM-Au8 and the wide applicability of its neuroprotective activities, Clene’s lead asset is being investigated in the clinic as a potential first-in-class drug for the treatment of multiple neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS) and Parkinson’s disease (PD). “The insights gained from this research provide, for the first time, important guiding principles for the rational design of a new class of gold-based catalytic therapeutic agents with energy metabolism-regulating and neuroprotective functions,” said Professor Wang, Ph.D., Department of Chemistry and Biochemistry, University of South Carolina and a senior co-author of the paper. Karen S. Ho, Ph.D., VP ...