Business
Clarivate Enhances OFF-X with Pathway Maps to Accelerate Target Safety Assessments
Clarivate Plc (NYSE:CLVT), a leading global provider of transformative intelligence, today announced the incorporation of Pathway Maps in OFF-X, a cutting-edge translational safety intelligence solution. With over 30% of drug development failures attributed to safety issues1, preclinical and translational research teams face increasing pressure to identify potential liabilities earlier in the target selection process. Pathway Maps provide powerful visual tools that offer deeper insights into the
About this update from Clarivate Plc
[{"type":"text","content":"R&D teams can streamline safety evaluations, reduce risks and enable faster decision-making in drug development using new visual and data-driven insights","length":157,"tagName":"p"},{"type":"text","content":"LONDON, May 14, 2025 /PRNewswire/ -- Clarivate Plc (NYSE:CLVT), a leading global provider of transformative intelligence, today announced the incorporation of Pathway Maps in OFF-X, a cutting-edge translational safety intelligence solution. With over 30% of drug development failures attributed to safety issues1, preclinical and translational research teams face increasing pressure to identify potential liabilities earlier in the target selection process. Pathway Maps provide powerful visual tools that offer deeper insights into the biological mechanisms underlying diseases and target interactions, streamlining target safety assessments and enabling faster, data-driven decisions.","length":697,"tagName":"p"},{"type":"image","alt":"Clarivate logo (PRNewsfoto/Clarivate Analytics)","displaySize":"","headline":null,"caption":"Clarivate logo (PRNewsfoto/Clarivate Analytics)","className":"","disableSlideshowImg":false,"size":{"original":{"width":400,"height":127,"url":"https://media.zenfs.com/en/prnewswire.com/0ccf29bb19b6eae58105fdbb6b41514f"},"resized":{"url":"https://s.yimg.com/ny/api/res/1.2/1UOZM6Hxg1qtBQRY71PEqQ--/YXBwaWQ9aGlnaGxhbmRlcjt3PTcwNTtoPTIyNDtjZj13ZWJw/https://media.zenfs.com/en/prnewswire.com/0ccf29bb19b6eae58105fdbb6b41514f","width":400,"height":127}},"href":"https://mma.prnewswire.com/media/1159266/Clarivate_Logo_v1.html","hrefExternal":true,"rel":"nofollow"},{"type":"text","content":"Traditional safety data collection is often fragmented and time-consuming, creating delays in critical go/no-go decisions. With the addition of Pathway Maps to OFF-X, researchers can now explore disease-specific visualizations of key signaling pathways and molecular processes—uniquely overlaid with curated, multi-source safety data. This integration enables users to quickly pinpoint potential safety liabilities across upstream or downstream targets, adding biological context to risk assessment. By bringing together visual disease biology and comprehensive safety intelligence in one platform, OFF-X addresses a critical industry gap—empowering teams to make faster, more confident decisions across the drug development li...