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U.S. Department of Defense Awards Funding for Study to Evaluate the Use of INTERCEPT Plasma in Traumatic Burn Resuscitation
Collaboration with the National Trauma Institute CONCORD, Calif.--(BUSINESS WIRE)-- Cerus Corporation (Nasdaq: CERS) today announced a collaboration with the
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[{"type":"text","content":"\nCollaboration with the National Trauma Institute\n\n CONCORD, Calif.--(BUSINESS WIRE)--\nCerus Corporation (Nasdaq: CERS) today announced a collaboration with the National Trauma Institute (NTI) to supply INTERCEPT plasma for use in the Plasma Resuscitation Without Lung Injury (PROpOLIs) clinical study. PROpOLIs is sponsored by NTI and funded by the United States Department of Defense Joint Program Committee 6 (JPC-6) Combat Casualty Care Research Program and the Congressionally Directed Medical Research Programs (CDMRP).\n\n\nBurn injuries remain a significant health burden in civilian, first responder, and military settings. Despite major advances in care over the past 25 years, morbidity and mortality remain high, possibly exacerbated by current burn resuscitation strategies that employ large-volume crystalloid administration. Fluid overload early after burn injury constitutes a major risk factor for development of pneumonia, acute respiratory disease syndrome (ARDS), multiorgan failure, and death. The major objective of this study is to evaluate INTERCEPT plasma as a safe and effective resuscitation fluid in patients with major burns.\n\n\n“The goal of this study is to improve the outcomes of patients being treated for major burns and to effect a volume-sparing intervention that reduces endothelial injury and consequent organ dysfunction,” says Obi Greenman, Cerus’ CEO. “We believe the successful outcome of this study could have implications for volume resuscitation across multiple indications in which crystalloid and colloid solutions have been used for early volume replacement.”\n\n\nResearch findings indicate that the endothelial injury (endotheliopathy) of burns (EoB) contributes to vascular leakage in patients with major burns. Endotheliopathy consists of damage to the cell layer lining blood vessels caused by burns, trauma, bleeding and infectious disease. This study assesses if EoB will be ameliorated by a change in burn resuscitation therapy from a crystalloid-based strategy to the incorporation of pathogen reduced plasma early after injury.\n\n\n“This study could have meaningful clinical implications for the care of burn patients. Fluid replacement that also corrects the endotheliopathy of burns may provide valuable clinical benefit, including reduced morbidity, shorter ICU stay, decreased hospital costs and impro...