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Iopofosine I 131 Featured in Two Separate Presentations at 12th International Workshop on Waldenstrom’s Macroglobulinemia
Jorge Castillo, M.D. to Present Iopofosine I 131 Activity in Bing-Neel Syndrome Andrei Shustov, M.D. to Review CLOVER WaM Pivotal Study FLORHAM PARK, N.J.,
About this update from Cellectar Biosciences, Inc.
[{"type":"text","content":"Jorge Castillo, M.D. to Present Iopofosine I 131 Activity in Bing-Neel Syndrome Andrei Shustov, M.D. to Review CLOVER WaM Pivotal Study FLORHAM PARK, N.J., Aug. 26, 2024 (GLOBE NEWSWIRE) -- Cellectar Biosciences, Inc. (NASDAQ: CLRB), a late-stage clinical biopharmaceutical company focused on the discovery, development and commercialization of drugs for the treatment of cancer, today announced two presentations: one regarding the treatment of a patient with Bing-Neel Syndrome (BNS), and a review of the company’s CLOVER WaM pivotal study of iopofosine I 131 at the 12th International Workshop on Waldenstrom’s Macroglobulinemia being held October 17-19, 2024, in Prague, Czech Republic. BNS is a rare, life-threatening complication of WM that manifests in the central nervous system (CNS). It typically translates into various neurological sequalae, such as neuropathy, headaches, visual disturbances, changes in gait, partial paralysis and is associated with poor outcomes. Up to 30% of patients diagnosed with BNS die within the first three years of diagnosis. Cellectar’s lead product candidate, iopofosine I 131, is a potential first-in-class, novel cancer targeting agent utilizing a phospholipid ether radioconjugate. Iopofosine has demonstrated the ability to cross the blood brain barrier with clinical activity in multiple hematologic malignancies that involve or occur within the CNS. This includes relapsed/refractory primary CNS lymphoma, which is most often the result of diffuse large B cell lymphoma infiltrating the CNS. At IWWM, a case study report will be presented by Jorge Castillo MD, associate professor of medicine, Harvard Medical School, and clinical director, Bing Center for Waldenstrom’s Macroglobulinemia Dana Farber Cancer Institute, demonstrating complete central nervous system clearance in a relapsed/refractory BNS patient treated with iopofosine I-131. In addition, Andrei Shustov MD, Cellectar’s senior vice president of medical, will review topline data from the fully enrolled and completed CLOVER WaM pivotal study, the first and largest WM study to date in a highly refractory patient population. “I look forward to Cellectar providing top line data on the activity of iopofosine in relapsed or refractory patients with Waldenstrom’s Macroglobulinemia at the 12th International Workshop on Waldenstrom’s Macroglobulinemia in P...