Business

Cellectar Biosciences Submits Phase 1b Clinical Trial Protocol to US Food and Drug Administration for CLR 125 to Treat Triple-Negative Breast Cancer (TNBC)

Good Tolerability and Robust Tumor Uptake were Observed in TNBC Animal Models Auger Emitters Offer the Potential Benefit of Enhanced Cytotoxicity, Safety and Ease-of-Use FLORHAM PARK, N.J., June 24, 2025 (GLOBE NEWSWIRE) -- Cellectar Biosciences, Inc. (Nasdaq: CLRB), a late-stage clinical biopharmaceutical company focused on the discovery and development of drugs for the treatment of cancer, today announced that the company has submitted a protocol with the U.S. Food and Drug Administration (FDA

articleCellectar Biosciences, Inc.June 24, 20255/company/cellectar-biosciences-inc/news/cellectar-biosciences-submits-phase-1b-123000611
Cellectar Biosciences Submits Phase 1b Clinical Trial Protocol to US Food and Drug Administration for CLR 125 to Treat Triple-Negative Breast Cancer (TNBC)

About this update from Cellectar Biosciences, Inc.

[{"type":"image","alt":"Cellectar Biosciences, Inc.","displaySize":"","headline":null,"caption":"Cellectar Biosciences, Inc.","className":"","disableSlideshowImg":false,"size":{"original":{"width":296,"height":300,"url":"https://media.zenfs.com/en/globenewswire.com/7baccc0d962891d85da2697559b3ccb0"},"resized":{"url":"https://s.yimg.com/ny/api/res/1.2/qCQXkIySESVHpCuJXj8EOw--/YXBwaWQ9aGlnaGxhbmRlcjt3PTQyMDtoPTQyNjtjZj13ZWJw/https://media.zenfs.com/en/globenewswire.com/7baccc0d962891d85da2697559b3ccb0","width":296,"height":300}},"lazy":false},{"type":"text","content":"Good Tolerability and Robust Tumor Uptake were Observed in TNBC Animal Models","length":77,"tagName":"p"},{"type":"text","content":"Auger Emitters Offer the Potential Benefit of Enhanced Cytotoxicity, Safety and Ease-of-Use","length":91,"tagName":"p"},{"type":"text","content":"FLORHAM PARK, N.J., June 24, 2025 (GLOBE NEWSWIRE) -- Cellectar Biosciences, Inc. (Nasdaq: CLRB), a late-stage clinical biopharmaceutical company focused on the discovery and development of drugs for the treatment of cancer, today announced that the company has submitted a protocol with the U.S. Food and Drug Administration (FDA) for a Phase 1b Dose Finding study of its Auger emitting radiopharmaceutical, CLR 125, for the treatment of relapsed TNBC. CLR 125 is an iodine-125 Auger-emitting drug candidate targeting solid tumors, such as triple negative breast, lung and colorectal cancers.","length":593,"tagName":"p"},{"type":"text","content":"“Building on the promising preclinical results with CLR 125, we have submitted a Phase 1b dose-finding study protocol to the FDA for the treatment of triple-negative breast cancer, including metastatic disease. This study leverages the unique potential ability of our PLE to deliver iodine-125 directly to the nucleus and mitochondria, which is designed to achieve potent activity while minimizing the risk of adverse effects due to its limited transmission range,” said Jarrod Longcor, Cellectar’s chief operating officer. “Initiating this Phase 1b study is a significant milestone and an important step toward evaluating the safety and optimal dosing of CLR 125 in patients, ultimately providing a potential new treatment option for those afflicted by this challenging disease.”","length":780,"tagName":"p"},{"type":"text","content":"The proposed Phase 1b dose finding study in relapsed TNBC wil...

More updates from Cellectar Biosciences, Inc.

breast cancerCellectar Biosciences, Inc.Food and Drug Administrationbiopharmaceutical companyPhase 1bCellectar BiosciencesPhase 2 clinical trialTNBCiodine-125study protocolsolid tumors