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Cellectar Biosciences Reports Complete Response in a Relapsed/Refractory CNS Lymphoma Patient
Response Achieved in Primary Central Nervous System Lymphoma for which there is no Approved Treatment FLORHAM PARK, N.J., Feb. 28, 2023 (GLOBE NEWSWIRE) --
About this update from Cellectar Biosciences, Inc.
[{"type":"text","content":"Response Achieved in Primary Central Nervous System Lymphoma for which there is no Approved Treatment\nFLORHAM PARK, N.J., Feb. 28, 2023 (GLOBE NEWSWIRE) -- Cellectar Biosciences, Inc. (NASDAQ: CLRB), a late-stage clinical biopharmaceutical company focused on the discovery, development and commercialization of drugs for the treatment of cancer, today announced that a patient with primary central nervous system lymphoma (PCNSL) enrolled in its Phase 2 CLOVER-1 Trial demonstrated a complete response according to the 2005 Response Criteria for CNS Lymphoma with total resolution of the tumor on imaging studies. Prior to study enrollment, the 61-year-old female patient was diagnosed with PCNSL, had received four lines of drug therapy including three lines of multi-drug therapy and a round of external beam radiation. She had BCL6 gene rearrangement which predicts worse outcomes and reduced survival. The patient was enrolled in the Phase 2 CLOVER-1 trial and received two cycles (four doses of 15mCi/m2) of iopofosine I 131 over 71 days with a total administered dose of ~100mCi. Each infusion lasted less than 30 minutes. 50 days post cycle 1 day 1 infusion, a CT scan showed a very good partial response (VGPR) with a 93% reduction in tumor volume. The patient was administered the second cycle of iopofosine I 131 on days 57 and 71 and demonstrated complete resolution of the tumor as determined by CT scan by day 92 from initial dosing. “Complete resolution of this patient’s primary CNS lymphoma, which had been relapsed or refractory to four lines of therapy, is extraordinary and provides further evidence of iopofosine’s ability to cross the blood/brain barrier and target cancer. Importantly, these patients currently have very poor prognoses and there is no approved therapy for CNS lymphoma,” said Dr. Andrei Shustov, senior vice president, medical of Cellectar. “Beyond iopofosine’s demonstrated activity across all Waldenstrom’s macroglobulinemia (WM) genotypes currently tested, it is our belief that iopofosine will also demonstrate activity in WM patients with CNS involvement such as patients with Bing Neel syndrome.” About CNS Lymphoma CNS lymphoma is a rare type of non-Hodgkin lymphoma (cancer of the lymph tissue) that develops in the central nervous system (CNS). It may form in the brain, spinal cord, spinal fluid or eye. When the lymphom...