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Cellectar Biosciences Announces Presentation of Data on CLR 12120 Series of Targeted Alpha-Emitting Therapies at the 13th Annual World ADC Conference
Preclinical data demonstrate ability to deliver targeted alpha-emitting isotopes to malignant cells and therapeutic efficacy FLORHAM PARK, N.J., Nov. 21, 2022
About this update from Cellectar Biosciences, Inc.
[{"type":"text","content":"Preclinical data demonstrate ability to deliver targeted alpha-emitting isotopes to malignant cells and therapeutic efficacy\nFLORHAM PARK, N.J., Nov. 21, 2022 (GLOBE NEWSWIRE) -- Cellectar Biosciences, Inc. (NASDAQ: CLRB), a late-stage clinical biopharmaceutical company focused on the discovery, development and commercialization of drugs for the treatment of cancer, today announced the presentation of preclinical data at the 13th Annual World ADC Conference supporting development of CLR 12120 series of targeted alpha therapies (TATs). The data demonstrate the versatility of the phospholipid ether (PLE) targeting platform and highlight the potential of the company’s alpha emitting precision medicines. The presentation entitled: \"Novel Conjugates – Radiotherapies,\" given by Cellectar’s Chief Operating Officer, Jarrod Longcor, reports data from multiple preclinical studies of the CLR 12120 series, a series of TAT drug candidates designed to target and deliver either actinium-225, lead-212, or astatine-211 to cancer cells. Results demonstrated high tumor delivery with low off-target uptake of the CLR 12120 compounds when administered as monotherapies. Further, the mouse model data showed therapeutic efficacy of all three CLR 12120 candidates at both single and multiple doses in preclinical pancreatic and triple negative breast cancer xenograft models. The targeting mechanism for the CLR 12120 series is based upon the company’s proprietary PLE delivery platform, which targets unique changes in the cancerous cell membranes versus normal/healthy cell membranes. The membrane of tumor cells are differentiated from normal cell membranes by unique microdomains that are present due to the increased metabolic needs of the cancer cells allowing for rapid, uncontrolled growth. These changes provide a novel and unique method to provide precision targeted delivery of various anticancer therapies to tumors. \"The data from our CLR 12120 series is highly encouraging and further validates the payload versatility and precision targeting of our PLE delivery platform,” said Jarrod Longcor, Chief Operating Officer. “The data confirm the ability of the PLEs to deliver nearly any radioisotopes including alpha- and beta-emitters directly to tumor cells. Furthermore, the efficacy data demonstrate the potential to treat highly aggressive and difficult to...