Business
Celldex Therapeutics Presents Positive Data from Barzolvolimab Phase 1b Study in Chronic Spontaneous Urticaria at AAAAI 2023
- Rapid, profound and durable responses across multiple dosing groups with favorable safety profile observed—positioning barzolimab as a potential
About this update from Celldex Therapeutics, Inc.
[{"type":"text","content":"- Rapid, profound and durable responses across multiple dosing groups with favorable safety profile observed—positioning barzolimab as a potential best-in-class addition to a historically limited treatment landscape - - At week 12, 56% of all patients in the 1.5 mg/kg, 3.0 mg/kg and 4.5 mg/kg dose groups had complete response and 76% had well-controlled disease (UAS7/UCT) - - At week 24, 53% of all patients in the 1.5 mg/kg and 3.0 mg/kg dose groups had complete response and 70% experienced well-controlled disease (UAS7/UCT); additional follow up ongoing in 4.5 mg/kg dose - - 37% of treated patients had prior omalizumab therapy and still had similar clinical benefit improvement as the overall population - - Company to host webcast on Sunday, February 26 at 4:00 pm CT/5:00 pm ET - HAMPTON, N.J., Feb. 26, 2023 (GLOBE NEWSWIRE) -- Celldex Therapeutics, Inc. (NASDAQ:CLDX) announced today updated data from the Company’s Phase 1b clinical trial of barzolvolimab in patients with moderate to severe chronic spontaneous urticaria (CSU) refractory to antihistamines. Barzolvolimab is a humanized monoclonal antibody that specifically binds the receptor tyrosine kinase KIT with high specificity and potently inhibits its activity, which is required for the function and survival of the mast cell. CSU is characterized by the occurrence of hives or wheals for 6 weeks or longer without identifiable specific triggers or causes. Treatment options for patients with CSU are limited and there are no approved therapies for patients who do not respond to omalizumab. The data were presented by Dr. Marcus Maurer, Professor of Dermatology and Allergy at Charité – Universitätsmedizin in Berlin, in a poster presentation (#410) as part of the American Academy of Allergy, Asthma & Immunology (AAAAI) Annual Meeting 2023. \"These exceptional results with barzolvolimab show its potential ability to bring meaningful improvements to patients suffering from this often very severe and debilitating disease,\" said Marcus Maurer, M.D. \"The novel mechanism of barzolvolimab in depleting mast cells offers a potential much needed treatment option for patients who suffer from chronic spontaneous urticaria, including patients who are not seeing meaningful benefits from the current standard of care. What’s more, these results distinguish barzolvolimab as a valuable tool to he...