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Spread of breast cancer accelerates during sleep
Spread of breast cancer accelerates during sleep.
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[{"type":"text","content":"\n \n \n \n \n \n \n \n For immediate release\n \n \n \n \n \n \n 27 June 2022\n \n \n \n \n \n \n \n \n \n \n \n \n \n ANGLE plc (\"the Company\")\n \n \n \n \n \n \n \n BREAKTHROUGH RESEARCH WITH PARSORTIX REVEALS SPREAD OF BREAST CANCER ACCELERATES DURING SLEEP\n \n \n \n \n \n \n \n \n \n CTCs, CTC clusters and CTC-WBC clusters harvested using Parsortix were more numerous and more aggressive in initiating metastasis during sleep\n \n \n \n \n \n \n \n \n \n Potential for optimisation of cancer care by utilising the Parsortix system in time-controlled approaches for treatment\n \n \n \n \n \n \n ANGLE plc (AIM:AGL OTCQX:ANPCY), a world-leading liquid biopsy company,\n is delighted to announce ground-breaking research by the world-class team at the Molecular Oncology Laboratory at the Swiss Federal Institute of Technology (ETH) Zurich, Switzerland. The study utilised the Parsortix® system to investigate the impact of sleep on the release of CTCs in preclinical models and 30 patients with breast cancer (21 with early stage and 9 with metastatic disease).\n \n \n \n \n \n The Parsortix system provided biomarker-independent isolation and harvest of CTCs, CTC clusters and CTC-white blood cell (WBC) clusters. This was crucial in enabling the researchers to develop a new understanding of cancer metastasis with the discovery that the release of CTCs, CTC clusters and CTC-WBC clusters is highly dependent on the circadian rhythm with far greater metastatic activity during the rest phase (i.e. during the night). Not only are more CTCs, CTC clusters and CTC-WBC clusters released during the rest phase, but gene expression analysis (RNA sequencing) found that genes relating to cell division and metastatic potential were consistently upregulated, leading to more aggressive cancer cells.\n \n \n \n \n \n These findings provide novel insight into the role of the circadian rhythm in the generation of CTCs with metastatic potential. This research could allow for the optimisation of cancer care by utilising time-controlled approaches for the treatment of breast cancer. For example, treatments which are most effective during the rest-phase, or which can reduce the impact of the circadian rhythm on CTC and CTC cluster release during the rest phase. The research also identified the role of key circadi...