Business
IMMUNE SUPPRESSOR CELLS PROMOTE METASTASIS
IMMUNE SUPPRESSOR CELLS PROMOTE METASTASIS.
About this update from Cellbxhealth Plc
[{"type":"text","content":"\n \nRNS Number : 1692X Angle PLC 26 April 2019 \n\n\n\n\n\n\n\nFor immediate release\n\n\n 26 April 2019\n \n\n\n\n\n\n\n\n\n\n\nANGLE plc (\"the Company\")\n \nBREAKTHROUGH RESEARCH USING THE PARSORTIX SYSTEM DISCOVERS ROLE OF BODY'S OWN IMMUNE SUPPRESSOR CELLS IN PROMOTING CANCER METASTASIS\n \nResearch using Parsortix discovers large CTC clusters of 10-30 cells comprising both cancer cells and immune suppressor cells, which dramatically increase cancer metastasis\n \nParsortix system offers key capabilities for research into CTC clusters to target new ways to disable the cancer-promoting role of immune suppressor cells\n \n \nANGLE plc (AIM:AGL OTCQX:ANPCY), a world-leading liquid biopsy company, is delighted to announce that its ParsortixTM system has been utilised in further groundbreaking new cancer research which demonstrates for the first time the role of myeloid-derived suppressor cells (MDSCs) as part of large circulating tumor cell (CTC) clusters, which are 50x more likely to generate metastasis than single CTCs.\n \nThe research, led by Professor Dario Marchetti at the Biomarker Research Program, Houston Methodist Research Institute (Houston, Texas, United States) in conjunction with the Center for Precision Health, University of Texas and MD Anderson Cancer Center has been published as a peer-reviewed publication in the International Journal of Molecular Sciences. \n \nThe research investigated metastatic breast and melanoma cancers and found that the Parsortix system harvested large CTC clusters comprising 10-30 cells in 100% of the patient samples (n=33). In contrast, a leading antibody CTC system was unable to capture large CTC clusters in any samples and only identified small CTC clusters comprising 2-3 cells in less than 50% of the samples.\n \nThe research work investigated for the first time the role of MDSCs in CTC clusters. MDSCs are a subset of the body's immune cells, which are distinct from neutrophils which have been separately studied by other ANGLE customers, and provide the body with a sophisticated mechanism to balance an extensive immune response to protect from excessive tissue damage and autoimmune disorders. MDSCs interact with other immune cell types including T cells, dendritic cells, macrophages and natural killer cell...