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Celcuity Presents Data at AACR Annual Meeting Assessing Gedatolisib, a pan-PI3K/mTOR Inhibitor, in HER2-negative Breast and Ovarian Cancer Patient Tumors with Hyperactive RAS Network Signaling
- Inhibition of hyperactive RAS network signaling is nine times more effective with gedatolisib than with a PI3K-α inhibitor -- Synergistic cooperation
About this update from Celcuity Inc.
[{"type":"text","content":"- Inhibition of hyperactive RAS network signaling is nine times more effective with gedatolisib than with a PI3K-α inhibitor -- Synergistic cooperation between PI3K/mTOR and BCL signaling detected, suggesting potential patient benefit of combining gedatolisib with a BCL inhibitor -MINNEAPOLIS, MN / ACCESSWIRE / April 12, 2021 / Celcuity Inc. (NASDAQ:CELC), a clinical-stage biotechnology company pursuing an integrated companion diagnostic (CDx) and therapeutic strategy for treating patients with cancer, presented results of studies evaluating gedatolisib (a pan-PI3K/mTOR inhibitor), inavolisib (a PI3K-α inhibitor), and navitoclax (a BCL inhibitor) in breast and ovarian patient tumors. Results were presented in two e-posters at the American Association for Cancer Research (AACR) Annual Meeting.The CELsignia RAS Network Activity test for breast and ovarian cancer identifies patients whose tumors have hyperactive RAS network signaling. The posters presented at AACR describe studies using this CELsignia test to characterize the role RAS network nodes, PI3K, mTOR, and BCL, play in phospholipid-initiated signaling activity via the lysophosphatidic acid (LPA) receptor family of GPCRs in breast and ovarian patient tumor cells and cell lines. Key findings included:Hyperactive RAS network signaling is more effectively inhibited with a pan-PI3K/mTOR inhibitor (gedatolisib) than a PI3K-α inhibitor (inavolisib).Gedatolisib inhibited nine times more signaling test activity in tumors with hyperactive RAS network signaling, on average, than inavolisib, when evaluated at equal concentrations with the CELsignia test.Gedatolisib at one-fifth the concentration of inavolisib (30 nM vs. 150 nM) inhibited five times more signaling activity as quantified by the CELsignia test.Synergistic cooperation between BCL and PI3K/mTOR inhibitors was detected, suggesting that addition of a BCL inhibitor like navitoclax to a pan-PI3K/mTOR inhibitor like gedatolisib may induce a greater anti-tumor effect.\"Results obtained during the development of our CELsignia RAS Network Activity test, such as those we presented at AACR this weekend, revealed the potential advantage of inhibiting all Class 1 PI3K isoforms and mTOR, not just PI3K-α signaling, when treating PI3K-involved signaling tumors,\" said Brian Sullivan, CEO and co-founder of Celcuity.The e-poster is availab...